ID   SPAP_SHISO              Reviewed;         216 AA.
AC   P0A1L4; P35529;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Surface presentation of antigens protein SpaP;
DE   AltName: Full=Spa24 protein;
GN   Name=spaP; Synonyms=spa24;
OS   Shigella sonnei.
OG   Plasmid pINV.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=624;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=HW383;
RA   Arakawa E., Kato J., Ito K., Watanabe H.;
RT   "Comparison and high conservation of nucleotide sequences of spa-mxi
RT   regions between S.sonnei and S.flexneri -- identification of a new gene
RT   coding plausible membrane protein.";
RL   Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for surface presentation of invasion plasmid
CC       antigens. Could play a role in preserving the translocation competence
CC       of the ipa antigens. Required for invasion and for secretion of the
CC       three Ipa proteins (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FliP/MopC/SpaP family. {ECO:0000305}.
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DR   EMBL; D50601; BAA09162.1; -; Genomic_DNA.
DR   AlphaFoldDB; P0A1L4; -.
DR   SMR; P0A1L4; -.
DR   STRING; 216599.GCA_000283715_05244; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   InterPro; IPR005838; T3SS_IM_P.
DR   InterPro; IPR005773; YopR.
DR   PANTHER; PTHR30587; PTHR30587; 1.
DR   Pfam; PF00813; FliP; 1.
DR   PRINTS; PR01302; TYPE3IMPPROT.
DR   TIGRFAMs; TIGR01102; yscR; 1.
DR   PROSITE; PS01060; FLIP_1; 1.
DR   PROSITE; PS01061; FLIP_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Plasmid; Transmembrane; Transmembrane helix;
KW   Virulence.
FT   CHAIN           1..216
FT                   /note="Surface presentation of antigens protein SpaP"
FT                   /id="PRO_0000191994"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   216 AA;  24200 MW;  8BB50BB4CAEB69F8 CRC64;
     MLSDMSLIAT LSFFTLLPFL VAAGTCYIKF SIVFVMVRNA LGLQQVPSNM TLNGIALIMA
     LFVMKPIIEA GYENYLNGPQ KFDTISDIVR FSDSGLMEYK QYLKKHTDLE LARFFQRSEE
     ENADLKSAEN NDYSLFSLLP AYALSEIKDA FKIGFYLYLP FVVVDLVISS ILLALGMMMM
     SPITISVPIK LVLFVALDGW GILSKALIEQ YINIPA