SPAR_SALTY
ID SPAR_SALTY Reviewed; 263 AA.
AC P40701;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Surface presentation of antigens protein SpaR;
GN Name=spaR; OrderedLocusNames=STM2888;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8404849; DOI=10.1002/j.1460-2075.1993.tb06056.x;
RA Groisman E.A., Ochman H.;
RT "Cognate gene clusters govern invasion of host epithelial cells by
RT Salmonella typhimurium and Shigella flexneri.";
RL EMBO J. 12:3779-3787(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Involved in a secretory pathway responsible for the surface
CC presentation of determinants needed for the entry of Salmonella species
CC into mammalian cells.
CC -!- INTERACTION:
CC P40701; P40700: spaP; NbExp=2; IntAct=EBI-15880134, EBI-15880102;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FliR/MopE/SpaR family. {ECO:0000305}.
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DR EMBL; X73525; CAA51926.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL21768.1; -; Genomic_DNA.
DR PIR; S37309; S37309.
DR RefSeq; NP_461809.1; NC_003197.2.
DR RefSeq; WP_000498965.1; NC_003197.2.
DR PDB; 6PEM; EM; 3.50 A; 5=1-263.
DR PDB; 6PEP; EM; 3.80 A; 5=1-263.
DR PDB; 6Q14; EM; 3.80 A; 5=1-263.
DR PDB; 6Q15; EM; 5.15 A; 5=1-263.
DR PDB; 6Q16; EM; 4.10 A; 5=1-263.
DR PDB; 7AGX; EM; 3.60 A; 1F=1-263.
DR PDB; 7AH9; EM; 3.30 A; 1F=1-263.
DR PDB; 7AHI; EM; 3.30 A; 1F=1-263.
DR PDBsum; 6PEM; -.
DR PDBsum; 6PEP; -.
DR PDBsum; 6Q14; -.
DR PDBsum; 6Q15; -.
DR PDBsum; 6Q16; -.
DR PDBsum; 7AGX; -.
DR PDBsum; 7AH9; -.
DR PDBsum; 7AHI; -.
DR AlphaFoldDB; P40701; -.
DR SMR; P40701; -.
DR DIP; DIP-59559N; -.
DR IntAct; P40701; 3.
DR STRING; 99287.STM2888; -.
DR TCDB; 3.A.6.1.3; the type iii (virulence-related) secretory pathway (iiisp) family.
DR PaxDb; P40701; -.
DR EnsemblBacteria; AAL21768; AAL21768; STM2888.
DR GeneID; 1254411; -.
DR KEGG; stm:STM2888; -.
DR PATRIC; fig|99287.12.peg.3044; -.
DR HOGENOM; CLU_063626_0_3_6; -.
DR OMA; CPQLNAF; -.
DR PhylomeDB; P40701; -.
DR BioCyc; SENT99287:STM2888-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0006605; P:protein targeting; IEA:InterPro.
DR InterPro; IPR002010; T3SS_IM_R.
DR InterPro; IPR006304; T3SS_SpaR/YscT.
DR PANTHER; PTHR30065; PTHR30065; 1.
DR Pfam; PF01311; Bac_export_1; 1.
DR PRINTS; PR00953; TYPE3IMRPROT.
DR TIGRFAMs; TIGR01401; fliR_like_III; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Virulence.
FT CHAIN 1..263
FT /note="Surface presentation of antigens protein SpaR"
FT /id="PRO_0000192059"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 263 AA; 28487 MW; B267D1EB643DA3C5 CRC64;
MFYALYFEIH HLVASAALGF ARVAPIFFFL PFLNSGVLSG APRNAIIILV ALGVWPHALN
EAPPFLSVAM IPLVLQEAAV GVMLGCLLSW PFWVMHALGC IIDNQRGATL SSSIDPANGI
DTSEMANFLN MFAAVVYLQN GGLVTMVDVL NKSYQLCDPM NECTPSLPPL LTFINQVAQN
ALVLASPVVL VLLLSEVFLG LLSRFAPQMN AFAISLTVKS GIAVLIMLLY FSPVLPDNVL
RLSFQATGLS SWFYERGATH VLE
