SPAR_SHIFL
ID SPAR_SHIFL Reviewed; 256 AA.
AC P0A1M6; P40706; Q8VSG7; Q9AFR9; Q9AJW0;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Surface presentation of antigens protein SpaR;
DE AltName: Full=Spa29 protein;
GN Name=spaR; Synonyms=spa29; OrderedLocusNames=CP0155;
OS Shigella flexneri.
OG Plasmid pWR100, Plasmid pMYSH6000, Plasmid pINV_F6_M1382, and
OG Plasmid pCP301.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=YSH6000 / Serotype 2a; PLASMID=pMYSH6000;
RX PubMed=8385666; DOI=10.1128/jb.175.8.2334-2346.1993;
RA Sasakawa C., Komatsu K., Tobe T., Suzuki T., Yoshikawa M.;
RT "Eight genes in region 5 that form an operon are essential for invasion of
RT epithelial cells by Shigella flexneri 2a.";
RL J. Bacteriol. 175:2334-2346(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=M90T / Serotype 5a; PLASMID=pWR100;
RX PubMed=11115111; DOI=10.1046/j.1365-2958.2000.02179.x;
RA Buchrieser C., Glaser P., Rusniok C., Nedjari H., d'Hauteville H.,
RA Kunst F., Sansonetti P.J., Parsot C.;
RT "The virulence plasmid pWR100 and the repertoire of proteins secreted by
RT the type III secretion apparatus of Shigella flexneri.";
RL Mol. Microbiol. 38:760-771(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=M90T / Serotype 5a; PLASMID=pWR100;
RX PubMed=11292750; DOI=10.1128/iai.69.5.3271-3285.2001;
RA Venkatesan M.M., Goldberg M.B., Rose D.J., Grotbeck E.J., Burland V.,
RA Blattner F.R.;
RT "Complete DNA sequence and analysis of the large virulence plasmid of
RT Shigella flexneri.";
RL Infect. Immun. 69:3271-3285(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=M1382 / Serotype 6; PLASMID=pINV_F6_M1382;
RX PubMed=14573649; DOI=10.1128/iai.71.11.6298-6306.2003;
RA Lan R., Stevenson G., Reeves P.R.;
RT "Comparison of two major forms of the Shigella virulence plasmid pINV:
RT positive selection is a major force driving the divergence.";
RL Infect. Immun. 71:6298-6306(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a; PLASMID=pCP301;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
CC -!- FUNCTION: Required for surface presentation of invasion plasmid
CC antigens. Could play a role in preserving the translocation competence
CC of the ipa antigens. Required for invasion and for secretion of the
CC three ipa proteins.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FliR/MopE/SpaR family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK18474.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; D13663; BAA02831.1; -; Genomic_DNA.
DR EMBL; AL391753; CAC05830.1; -; Genomic_DNA.
DR EMBL; AF348706; AAK18474.1; ALT_INIT; Genomic_DNA.
DR EMBL; AY206439; AAP79018.1; -; Genomic_DNA.
DR EMBL; AF386526; AAL72306.2; -; Genomic_DNA.
DR PIR; I49846; I49846.
DR RefSeq; NP_085318.1; NC_002698.1.
DR RefSeq; NP_858288.2; NC_004851.1.
DR RefSeq; WP_031942476.1; NZ_QWST01000007.1.
DR RefSeq; YP_009062512.1; NC_024996.1.
DR PDB; 6R6B; EM; 3.50 A; F=1-256.
DR PDB; 6RWY; EM; 5.11 A; f=1-256.
DR PDBsum; 6R6B; -.
DR PDBsum; 6RWY; -.
DR AlphaFoldDB; P0A1M6; -.
DR SMR; P0A1M6; -.
DR STRING; 198214.CP0155; -.
DR TCDB; 3.A.6.1.2; the type iii (virulence-related) secretory pathway (iiisp) family.
DR EnsemblBacteria; AAL72306; AAL72306; SF_p0155.
DR GeneID; 1238002; -.
DR KEGG; sfl:CP0155; -.
DR PATRIC; fig|198214.7.peg.5400; -.
DR HOGENOM; CLU_063626_0_3_6; -.
DR Proteomes; UP000001006; Plasmid pCP301.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006605; P:protein targeting; IEA:InterPro.
DR InterPro; IPR002010; T3SS_IM_R.
DR InterPro; IPR006304; T3SS_SpaR/YscT.
DR PANTHER; PTHR30065; PTHR30065; 1.
DR Pfam; PF01311; Bac_export_1; 1.
DR PRINTS; PR00953; TYPE3IMRPROT.
DR TIGRFAMs; TIGR01401; fliR_like_III; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Membrane; Plasmid; Reference proteome;
KW Transmembrane; Transmembrane helix; Virulence.
FT CHAIN 1..256
FT /note="Surface presentation of antigens protein SpaR"
FT /id="PRO_0000192060"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 168
FT /note="I -> V (in plasmid pMYSH6000, plasmid pCP301 and
FT plasmid pINV_F6_M1382)"
FT HELIX 12..28
FT /evidence="ECO:0007829|PDB:6R6B"
FT HELIX 41..55
FT /evidence="ECO:0007829|PDB:6R6B"
FT TURN 56..59
FT /evidence="ECO:0007829|PDB:6R6B"
FT HELIX 73..89
FT /evidence="ECO:0007829|PDB:6R6B"
FT HELIX 91..107
FT /evidence="ECO:0007829|PDB:6R6B"
FT TURN 113..115
FT /evidence="ECO:0007829|PDB:6R6B"
FT HELIX 127..140
FT /evidence="ECO:0007829|PDB:6R6B"
FT HELIX 143..157
FT /evidence="ECO:0007829|PDB:6R6B"
FT STRAND 160..162
FT /evidence="ECO:0007829|PDB:6R6B"
FT STRAND 171..173
FT /evidence="ECO:0007829|PDB:6R6B"
FT HELIX 174..205
FT /evidence="ECO:0007829|PDB:6R6B"
FT HELIX 212..229
FT /evidence="ECO:0007829|PDB:6R6B"
FT TURN 234..237
FT /evidence="ECO:0007829|PDB:6R6B"
FT HELIX 238..248
FT /evidence="ECO:0007829|PDB:6R6B"
FT TURN 249..253
FT /evidence="ECO:0007829|PDB:6R6B"
SQ SEQUENCE 256 AA; 28498 MW; 4B081B38D1FC2A7F CRC64;
MDISSWFESI HVFLILLNGV FFRLAPLFFF LPFLNNGIIS PSIRIPVIFL VASGLITSGK
VDIGSSVFEH VYFLMFKEII VGLLLSFCLS LPFWIFHAVG SIIDNQRGAT LSSSIDPANG
VDTSELAKFF NLFSAVVFLY SGGMVFILES IQLSYNICPL FSQCSFRISN ILTFLTLLAS
QAVILASPVM IVLLLSEVLL GVLSRFAPQM NAFSVSLTIK SLLAIFIIFI CSSTIYFSKV
QFFLGEHKFF TNLFVR