ID   SPAR_SHISO              Reviewed;         256 AA.
AC   P0A1M7; P40706; Q8VSG7; Q9AFR9; Q9AJW0;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Surface presentation of antigens protein SpaR;
DE   AltName: Full=Spa29 protein;
GN   Name=spaR; Synonyms=spa29;
OS   Shigella sonnei.
OG   Plasmid pINV.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=624;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=HW383;
RA   Arakawa E., Kato J., Ito K., Watanabe H.;
RT   "Comparison and high conservation of nucleotide sequences of spa-mxi
RT   regions between S.sonnei and S.flexneri -- identification of a new gene
RT   coding plausible membrane protein.";
RL   Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for surface presentation of invasion plasmid
CC       antigens. Could play a role in preserving the translocation competence
CC       of the ipa antigens. Required for invasion and for secretion of the
CC       three ipa proteins (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FliR/MopE/SpaR family. {ECO:0000305}.
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DR   EMBL; D50601; BAA09164.1; -; Genomic_DNA.
DR   RefSeq; WP_000355395.1; NZ_UIQD01000016.1.
DR   AlphaFoldDB; P0A1M7; -.
DR   SMR; P0A1M7; -.
DR   STRING; 216599.GCA_000283715_05246; -.
DR   OMA; CPQLNAF; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006605; P:protein targeting; IEA:InterPro.
DR   InterPro; IPR002010; T3SS_IM_R.
DR   InterPro; IPR006304; T3SS_SpaR/YscT.
DR   PANTHER; PTHR30065; PTHR30065; 1.
DR   Pfam; PF01311; Bac_export_1; 1.
DR   PRINTS; PR00953; TYPE3IMRPROT.
DR   TIGRFAMs; TIGR01401; fliR_like_III; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Plasmid; Transmembrane; Transmembrane helix;
KW   Virulence.
FT   CHAIN           1..256
FT                   /note="Surface presentation of antigens protein SpaR"
FT                   /id="PRO_0000192061"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   256 AA;  28484 MW;  55E705C93EE2C57F CRC64;
     MDISSWFESI HVFLILLNGV FFRLAPLFFF LPFLNNGIIS PSIRIPVIFL VASGLITSGK
     VDIGSSVFEH VYFLMFKEII VGLLLSFCLS LPFWIFHAVG SIIDNQRGAT LSSSIDPANG
     VDTSELAKFF NLFSAVVFLY SGGMVFILES IQLSYNICPL FSQCSFRVSN ILTFLTLLAS
     QAVILASPVM IVLLLSEVLL GVLSRFAPQM NAFSVSLTIK SLLAIFIIFI CSSTIYFSKV
     QFFLGEHKFF TNLFVR