SPAS1_HUMAN
ID SPAS1_HUMAN Reviewed; 300 AA.
AC Q496A3; Q496A2; Q496A5; Q96LJ0;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Spermatogenesis-associated serine-rich protein 1;
GN Name=SPATS1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP ARG-8.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q496A3; Q86V38: ATN1; NbExp=3; IntAct=EBI-3923692, EBI-11954292;
CC Q496A3; P55212: CASP6; NbExp=3; IntAct=EBI-3923692, EBI-718729;
CC Q496A3; P28329-3: CHAT; NbExp=3; IntAct=EBI-3923692, EBI-25837549;
CC Q496A3; P02489: CRYAA; NbExp=3; IntAct=EBI-3923692, EBI-6875961;
CC Q496A3; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-3923692, EBI-11962928;
CC Q496A3; P41091: EIF2S3; NbExp=3; IntAct=EBI-3923692, EBI-1054228;
CC Q496A3; O75460-2: ERN1; NbExp=3; IntAct=EBI-3923692, EBI-25852368;
CC Q496A3; P22607: FGFR3; NbExp=3; IntAct=EBI-3923692, EBI-348399;
CC Q496A3; Q0VDC6: FKBP1A; NbExp=3; IntAct=EBI-3923692, EBI-10226858;
CC Q496A3; Q14957: GRIN2C; NbExp=3; IntAct=EBI-3923692, EBI-8285963;
CC Q496A3; P06396: GSN; NbExp=3; IntAct=EBI-3923692, EBI-351506;
CC Q496A3; P54652: HSPA2; NbExp=3; IntAct=EBI-3923692, EBI-356991;
CC Q496A3; Q7L273: KCTD9; NbExp=3; IntAct=EBI-3923692, EBI-4397613;
CC Q496A3; Q92876: KLK6; NbExp=3; IntAct=EBI-3923692, EBI-2432309;
CC Q496A3; P13473-2: LAMP2; NbExp=3; IntAct=EBI-3923692, EBI-21591415;
CC Q496A3; Q8IVT2: MISP; NbExp=3; IntAct=EBI-3923692, EBI-2555085;
CC Q496A3; O43920: NDUFS5; NbExp=3; IntAct=EBI-3923692, EBI-1246091;
CC Q496A3; Q96CV9: OPTN; NbExp=3; IntAct=EBI-3923692, EBI-748974;
CC Q496A3; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-3923692, EBI-5280197;
CC Q496A3; P62826: RAN; NbExp=3; IntAct=EBI-3923692, EBI-286642;
CC Q496A3; P49591: SARS1; NbExp=3; IntAct=EBI-3923692, EBI-1053431;
CC Q496A3; Q5JTV8: TOR1AIP1; NbExp=3; IntAct=EBI-3923692, EBI-2559665;
CC Q496A3; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-3923692, EBI-741480;
CC Q496A3; Q15915: ZIC1; NbExp=3; IntAct=EBI-3923692, EBI-11963196;
CC Q496A3; Q9Y649; NbExp=3; IntAct=EBI-3923692, EBI-25900580;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q496A3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q496A3-2; Sequence=VSP_028787;
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
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DR EMBL; AK058171; BAB71701.1; -; mRNA.
DR EMBL; BC100956; AAI00957.1; -; mRNA.
DR EMBL; BC100957; AAI00958.1; -; mRNA.
DR EMBL; BC100958; AAI00959.1; -; mRNA.
DR EMBL; BC100959; AAI00960.1; -; mRNA.
DR EMBL; BC110065; AAI10066.1; -; mRNA.
DR EMBL; BC111414; AAI11415.1; -; mRNA.
DR CCDS; CCDS4911.1; -. [Q496A3-1]
DR RefSeq; NP_659463.1; NM_145026.3. [Q496A3-1]
DR AlphaFoldDB; Q496A3; -.
DR BioGRID; 128721; 12.
DR IntAct; Q496A3; 32.
DR STRING; 9606.ENSP00000424400; -.
DR iPTMnet; Q496A3; -.
DR PhosphoSitePlus; Q496A3; -.
DR BioMuta; SPATS1; -.
DR MassIVE; Q496A3; -.
DR PaxDb; Q496A3; -.
DR PeptideAtlas; Q496A3; -.
DR PRIDE; Q496A3; -.
DR ProteomicsDB; 61985; -. [Q496A3-1]
DR Antibodypedia; 56365; 115 antibodies from 20 providers.
DR DNASU; 221409; -.
DR Ensembl; ENST00000288390.2; ENSP00000424400.1; ENSG00000249481.7. [Q496A3-1]
DR Ensembl; ENST00000323108.12; ENSP00000437552.1; ENSG00000249481.7. [Q496A3-1]
DR Ensembl; ENST00000674044.1; ENSP00000501191.1; ENSG00000249481.7. [Q496A3-1]
DR GeneID; 221409; -.
DR KEGG; hsa:221409; -.
DR MANE-Select; ENST00000674044.1; ENSP00000501191.1; NM_001372081.1; NP_001359010.1.
DR UCSC; uc003oxk.4; human. [Q496A3-1]
DR CTD; 221409; -.
DR DisGeNET; 221409; -.
DR GeneCards; SPATS1; -.
DR HGNC; HGNC:22957; SPATS1.
DR HPA; ENSG00000249481; Group enriched (epididymis, fallopian tube, testis).
DR neXtProt; NX_Q496A3; -.
DR PharmGKB; PA134922278; -.
DR VEuPathDB; HostDB:ENSG00000249481; -.
DR eggNOG; ENOG502S4JT; Eukaryota.
DR GeneTree; ENSGT00390000006786; -.
DR HOGENOM; CLU_081878_0_0_1; -.
DR InParanoid; Q496A3; -.
DR OMA; IPTLPFW; -.
DR OrthoDB; 1532791at2759; -.
DR PhylomeDB; Q496A3; -.
DR TreeFam; TF337302; -.
DR PathwayCommons; Q496A3; -.
DR SignaLink; Q496A3; -.
DR BioGRID-ORCS; 221409; 26 hits in 1063 CRISPR screens.
DR GenomeRNAi; 221409; -.
DR Pharos; Q496A3; Tbio.
DR PRO; PR:Q496A3; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q496A3; protein.
DR Bgee; ENSG00000249481; Expressed in right uterine tube and 46 other tissues.
DR ExpressionAtlas; Q496A3; baseline and differential.
DR Genevisible; Q496A3; HS.
DR InterPro; IPR029165; SASRP1.
DR PANTHER; PTHR35845; PTHR35845; 1.
DR Pfam; PF15160; SASRP1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..300
FT /note="Spermatogenesis-associated serine-rich protein 1"
FT /id="PRO_0000307694"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 113
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q811V6"
FT VAR_SEQ 1..115
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028787"
FT VARIANT 8
FT /note="G -> R (in dbSNP:rs10948132)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_036631"
FT CONFLICT 277
FT /note="N -> I (in Ref. 2; AAI00957)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 300 AA; 33705 MW; 20A052131D2E4D98 CRC64;
MSPSMLTGNS PRGCRLPSIS STTCGRQLEK VPEKRDSGMT EVERTYSANC SDFLESKGCF
ANTTPSGKSV SSSSSVETGP SVSEPPGLPR VSAYVDTTAD LDRKLSFSHS DHSSEMSLPE
VQKDKYPEEF SLLKLQTKDG HRPEWTFYPR FSSNIHTYHV GKQCFFNGVF LGNKRSLSER
TVDKCFGRKK YDIDPRNGIP KLTPGDNPYM YPEQSKGFHK AGSMLPPVNF SIVPYEKKFD
TFIPLEPLPQ IPNLPFWVKE KANSLKNEIQ EVEELDNWQP AVPLMHMLHL SGALDFPRQS
