SPAT4_HUMAN
ID SPAT4_HUMAN Reviewed; 305 AA.
AC Q8NEY3; Q8NCS5; Q8WW15;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Spermatogenesis-associated protein 4;
DE AltName: Full=Testis and spermatogenesis cell-related protein 2;
DE AltName: Full=Testis spermatocyte apoptosis-related gene 2 protein;
GN Name=SPATA4; Synonyms=TSARG2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=12019456;
RA Liu S.F., Li L.Y., Fu J.J., Liu G., Xing X.W., Lu G.X.;
RT "Rapid identification of human testis spermatocyte apoptosis-related gene,
RT TSARG2, by nested PCR and draft human genome searching.";
RL Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:378-382(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=15158438; DOI=10.1016/j.bbrc.2004.04.160;
RA Liu S.F., Lu G.X., Liu G., Xing X.W., Li L.Y., Wang Z.;
RT "Cloning of a full-length cDNA of human testis-specific spermatogenic cell
RT apoptosis inhibitor TSARG2 as a candidate oncogene.";
RL Biochem. Biophys. Res. Commun. 319:32-40(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION.
RX PubMed=26424010; DOI=10.1248/bpb.b15-00117;
RA Jiang J., Li L., Xie M., Fuji R., Liu S., Yin X., Li G., Wang Z.;
RT "SPATA4 Counteracts Etoposide-Induced Apoptosis via Modulating Bcl-2 Family
RT Proteins in HeLa Cells.";
RL Biol. Pharm. Bull. 38:1458-1463(2015).
CC -!- FUNCTION: May play a role in apoptosis regulation.
CC {ECO:0000269|PubMed:26424010}.
CC -!- INTERACTION:
CC Q8NEY3; Q8IUQ4: SIAH1; NbExp=3; IntAct=EBI-7067221, EBI-747107;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15158438}.
CC -!- TISSUE SPECIFICITY: Highly expressed in testis, the expression is
CC observed precisely in seminiferous tubules.
CC {ECO:0000269|PubMed:15158438}.
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DR EMBL; AY040204; AAK72463.1; -; mRNA.
DR EMBL; BC021731; AAH21731.1; -; mRNA.
DR CCDS; CCDS3826.1; -.
DR RefSeq; NP_653245.2; NM_144644.3.
DR AlphaFoldDB; Q8NEY3; -.
DR SMR; Q8NEY3; -.
DR BioGRID; 126337; 6.
DR IntAct; Q8NEY3; 2.
DR MINT; Q8NEY3; -.
DR STRING; 9606.ENSP00000280191; -.
DR iPTMnet; Q8NEY3; -.
DR PhosphoSitePlus; Q8NEY3; -.
DR BioMuta; SPATA4; -.
DR DMDM; 48474486; -.
DR MassIVE; Q8NEY3; -.
DR PaxDb; Q8NEY3; -.
DR PeptideAtlas; Q8NEY3; -.
DR PRIDE; Q8NEY3; -.
DR ProteomicsDB; 73237; -.
DR Antibodypedia; 17256; 149 antibodies from 26 providers.
DR DNASU; 132851; -.
DR Ensembl; ENST00000280191.7; ENSP00000280191.2; ENSG00000150628.7.
DR GeneID; 132851; -.
DR KEGG; hsa:132851; -.
DR MANE-Select; ENST00000280191.7; ENSP00000280191.2; NM_144644.4; NP_653245.2.
DR UCSC; uc003iuo.2; human.
DR CTD; 132851; -.
DR GeneCards; SPATA4; -.
DR HGNC; HGNC:17333; SPATA4.
DR HPA; ENSG00000150628; Tissue enriched (testis).
DR MIM; 609879; gene.
DR neXtProt; NX_Q8NEY3; -.
DR OpenTargets; ENSG00000150628; -.
DR PharmGKB; PA38232; -.
DR VEuPathDB; HostDB:ENSG00000150628; -.
DR eggNOG; ENOG502QU8V; Eukaryota.
DR GeneTree; ENSGT00910000144159; -.
DR HOGENOM; CLU_077979_1_0_1; -.
DR InParanoid; Q8NEY3; -.
DR OMA; SYQMHLP; -.
DR OrthoDB; 1471531at2759; -.
DR PhylomeDB; Q8NEY3; -.
DR TreeFam; TF323506; -.
DR PathwayCommons; Q8NEY3; -.
DR SignaLink; Q8NEY3; -.
DR BioGRID-ORCS; 132851; 15 hits in 1061 CRISPR screens.
DR ChiTaRS; SPATA4; human.
DR GenomeRNAi; 132851; -.
DR Pharos; Q8NEY3; Tbio.
DR PRO; PR:Q8NEY3; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8NEY3; protein.
DR Bgee; ENSG00000150628; Expressed in sperm and 109 other tissues.
DR ExpressionAtlas; Q8NEY3; baseline and differential.
DR Genevisible; Q8NEY3; HS.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0051493; P:regulation of cytoskeleton organization; IBA:GO_Central.
DR Gene3D; 1.10.418.10; -; 1.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR010441; CH_2.
DR InterPro; IPR036872; CH_dom_sf.
DR Pfam; PF06294; CH_2; 1.
DR PROSITE; PS50021; CH; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..305
FT /note="Spermatogenesis-associated protein 4"
FT /id="PRO_0000072101"
FT DOMAIN 49..155
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT VARIANT 149
FT /note="Y -> C (in dbSNP:rs17062589)"
FT /id="VAR_051369"
FT CONFLICT 70
FT /note="N -> D (in Ref. 3; AAH21731)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 305 AA; 34751 MW; 7A3D1DCDC3FAC976 CRC64;
MAAAGQEKGY LTQTAAALDK SPSLSPQLAA PIRGRPKKCL VYPHAPKSSR LSRSVLRWLQ
GLDLSFFPRN INRDFSNGFL IAEIFCIYYP WELELSSFEN GTSLKVKLDN WAQLEKFLAR
KKFKLPKELI HGTIHCKAGV PEILIEEVYT LLTHREIKSI QDDFVNFTDY SYQMRLPLVS
RSTVSKSIKD NIRLSELLSN PNMLTNELKA EFLILLHMLQ RKLGRKLNPE WFDVKPTVGE
VTLNHLPAQA SGRRYNLKVK RGRVVPVLPN IGSGGSSHRE IHVKQAGQHS YYSAMKPIRN
MDKKP
