ID   SPAT7_RAT               Reviewed;         526 AA.
AC   Q9R0A3;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Spermatogenesis-associated protein 7 homolog;
DE   AltName: Full=Fertility-related protein WMP1;
DE   AltName: Full=Rat sperm DNA no.3;
DE            Short=RSD-3;
GN   Name=Spata7; Synonyms=Rsd3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Wistar; TISSUE=Testis;
RX   PubMed=12736779; DOI=10.1007/s00109-003-0434-y;
RA   Zhang X., Liu H., Zhang Y., Qiao Y., Miao S.Y., Wang L., Zhang J., Zong S.,
RA   Koide S.S.;
RT   "A novel gene, RSD-3/HSD-3.1, encodes a meiotic-related protein expressed
RT   in rat and human testis.";
RL   J. Mol. Med. 81:380-387(2003).
CC   -!- FUNCTION: Involved in the maintenance of both rod and cone
CC       photoreceptor cells (By similarity). Required for photoreceptor-
CC       specific localization of proximal connecting cilium (CC) proteins RPGR,
CC       AHI1, NPHP1, NPHP4, and RPGRIP1 at the distal CC, a photoreceptor-
CC       specific extension of the primary cilium transition zone (By
CC       similarity). Maintenance of protein localization at the photoreceptor-
CC       specific distal CC is essential for normal microtubule stability and to
CC       prevent photoreceptor degeneration (By similarity).
CC       {ECO:0000250|UniProtKB:Q80VP2}.
CC   -!- SUBUNIT: Found in a complex with CFAP410, NEK1 and SPATA7 (By
CC       similarity). Interacts with NEK1 (By similarity). Interacts with
CC       RPGRIP1 (By similarity). Interacts with RPGR (By similarity). Interacts
CC       with NPHP4 (By similarity). Interacts with NPHP1 (By similarity).
CC       Interacts with AHI1 (By similarity). {ECO:0000250|UniProtKB:Q80VP2,
CC       ECO:0000250|UniProtKB:Q9P0W8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:Q9P0W8}. Cytoplasm, cytoskeleton, cilium basal
CC       body {ECO:0000250|UniProtKB:Q9P0W8}. Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q9P0W8}. Cell projection, cilium, photoreceptor
CC       outer segment {ECO:0000250|UniProtKB:Q80VP2}. Note=Localizes to the
CC       microtubule network. {ECO:0000250|UniProtKB:Q9P0W8}.
CC   -!- TISSUE SPECIFICITY: In early prophase of primary spermatocytes.
CC       {ECO:0000269|PubMed:12736779}.
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DR   EMBL; AF094609; AAF01783.1; -; mRNA.
DR   AlphaFoldDB; Q9R0A3; -.
DR   STRING; 10116.ENSRNOP00000005297; -.
DR   PaxDb; Q9R0A3; -.
DR   UCSC; RGD:621010; rat.
DR   RGD; 621010; Spata7.
DR   eggNOG; ENOG502QSVU; Eukaryota.
DR   InParanoid; Q9R0A3; -.
DR   PhylomeDB; Q9R0A3; -.
DR   PRO; PR:Q9R0A3; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0015630; C:microtubule cytoskeleton; ISS:UniProtKB.
DR   GO; GO:0032391; C:photoreceptor connecting cilium; ISS:UniProtKB.
DR   GO; GO:0120206; C:photoreceptor distal connecting cilium; ISO:RGD.
DR   GO; GO:0120200; C:rod photoreceptor outer segment; ISO:RGD.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; ISO:RGD.
DR   GO; GO:0045494; P:photoreceptor cell maintenance; ISS:UniProtKB.
DR   GO; GO:1903621; P:protein localization to photoreceptor connecting cilium; ISS:UniProtKB.
DR   GO; GO:1903546; P:protein localization to photoreceptor outer segment; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; IEP:RGD.
DR   InterPro; IPR029357; SPATA7.
DR   PANTHER; PTHR14917; PTHR14917; 1.
DR   Pfam; PF15244; HSD3; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..526
FT                   /note="Spermatogenesis-associated protein 7 homolog"
FT                   /id="PRO_0000072106"
FT   REGION          203..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        211..226
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   526 AA;  59983 MW;  C6538075F256DB65 CRC64;
     MAVHYNKILS AKAAVDCSIP VSVNASIKYA DQQRREKLRK ELARCEKEFK LSKSAMQTNS
     KMNSKFFVNS LQRPSGEPQD QDVLIEERLT RYPSFSKSLI PSPEGLHLSL PESNKILMNG
     TQKYPSTAPP RYSGCGHGYD RRPRSAHQFQ VVISKTPSGD LLEKHADLFS NNQSPFTPRT
     LKTEAKSFLS QYRYYTPAKR RRDFSDQRME AETQTELSSF NSELGTAEKK SSKDSDVSIK
     QAPNYMRNGA EDKIAPLSLQ GQNLAWDKSK DGILQPSSER APCTQFSPDS KIYSDEEELL
     YLSFMENVTD EILKLGLFSN RFLERLFERH IRKNKHHLEE GKMRYLLHGL KVDLGCISEE
     EQNSFRIFNE FHFQKALTSR ENRFINDTEA VNHHERQQYQ EALNMLSSVP KDENKMFSFP
     GEFLLPAHKV KHSEGVIVQQ VNDETDFEAL PWDGNNPSVS DSFIDQETSV DVIEGDSDFE
     MVETSRELCC LSTSLSPSVP LPSIEGGSNH DKELSTLKIM EMSIED