SPAT8_HUMAN
ID SPAT8_HUMAN Reviewed; 105 AA.
AC Q6RVD6; Q2KJ07;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Spermatogenesis-associated protein 8;
DE AltName: Full=Spermatogenesis-related protein 8;
GN Name=SPATA8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=16809841; DOI=10.1007/bf02728971;
RA Nie D., Xiang Y.;
RT "Molecular cloning and characterization of a novel human testis-specific
RT gene by use of digital differential display.";
RL J. Genet. 85:57-62(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6RVD6; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-8635958, EBI-10173507;
CC Q6RVD6; Q96DZ9: CMTM5; NbExp=3; IntAct=EBI-8635958, EBI-2548702;
CC Q6RVD6; P27658: COL8A1; NbExp=3; IntAct=EBI-8635958, EBI-747133;
CC Q6RVD6; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-8635958, EBI-3867333;
CC Q6RVD6; O95967: EFEMP2; NbExp=3; IntAct=EBI-8635958, EBI-743414;
CC Q6RVD6; Q9HD26: GOPC; NbExp=3; IntAct=EBI-8635958, EBI-349832;
CC Q6RVD6; P28799: GRN; NbExp=3; IntAct=EBI-8635958, EBI-747754;
CC Q6RVD6; P52597: HNRNPF; NbExp=3; IntAct=EBI-8635958, EBI-352986;
CC Q6RVD6; P04792: HSPB1; NbExp=3; IntAct=EBI-8635958, EBI-352682;
CC Q6RVD6; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-8635958, EBI-10172290;
CC Q6RVD6; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-8635958, EBI-10172052;
CC Q6RVD6; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-8635958, EBI-11962084;
CC Q6RVD6; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-8635958, EBI-1044640;
CC Q6RVD6; Q99750: MDFI; NbExp=6; IntAct=EBI-8635958, EBI-724076;
CC Q6RVD6; Q13064: MKRN3; NbExp=3; IntAct=EBI-8635958, EBI-2340269;
CC Q6RVD6; P40692: MLH1; NbExp=3; IntAct=EBI-8635958, EBI-744248;
CC Q6RVD6; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-8635958, EBI-742948;
CC Q6RVD6; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-8635958, EBI-11522433;
CC Q6RVD6; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-8635958, EBI-945833;
CC Q6RVD6; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-8635958, EBI-22310682;
CC Q6RVD6; O43933: PEX1; NbExp=3; IntAct=EBI-8635958, EBI-988601;
CC Q6RVD6; O15162: PLSCR1; NbExp=3; IntAct=EBI-8635958, EBI-740019;
CC Q6RVD6; P25788: PSMA3; NbExp=3; IntAct=EBI-8635958, EBI-348380;
CC Q6RVD6; Q93062: RBPMS; NbExp=4; IntAct=EBI-8635958, EBI-740322;
CC Q6RVD6; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-8635958, EBI-396669;
CC Q6RVD6; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-8635958, EBI-750487;
CC Q6RVD6; O76024: WFS1; NbExp=3; IntAct=EBI-8635958, EBI-720609;
CC Q6RVD6; P36508: ZNF76; NbExp=3; IntAct=EBI-8635958, EBI-7254550;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6RVD6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6RVD6-2; Sequence=VSP_023281;
CC -!- TISSUE SPECIFICITY: Expressed at high levels in adult testis, at
CC moderate levels in sperm and at low levels in fetal testis. Not
CC detected in other tissues. {ECO:0000269|PubMed:16809841}.
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DR EMBL; AY489187; AAR39432.1; -; mRNA.
DR EMBL; BC033979; AAH33979.1; -; mRNA.
DR EMBL; BC066292; AAH66292.1; -; mRNA.
DR EMBL; BC112390; AAI12391.1; -; mRNA.
DR RefSeq; NP_001291733.1; NM_001304804.1.
DR RefSeq; NP_001291734.1; NM_001304805.1.
DR RefSeq; NP_001291735.1; NM_001304806.1.
DR RefSeq; NP_775770.1; NM_173499.4.
DR AlphaFoldDB; Q6RVD6; -.
DR BioGRID; 126956; 30.
DR IntAct; Q6RVD6; 31.
DR MINT; Q6RVD6; -.
DR STRING; 9606.ENSP00000328149; -.
DR iPTMnet; Q6RVD6; -.
DR PhosphoSitePlus; Q6RVD6; -.
DR BioMuta; SPATA8; -.
DR DMDM; 74738039; -.
DR PaxDb; Q6RVD6; -.
DR PRIDE; Q6RVD6; -.
DR ProteomicsDB; 67327; -. [Q6RVD6-1]
DR DNASU; 145946; -.
DR UCSC; uc002bue.4; human. [Q6RVD6-1]
DR GeneCards; SPATA8; -.
DR HGNC; HGNC:28676; SPATA8.
DR MIM; 613948; gene.
DR neXtProt; NX_Q6RVD6; -.
DR PharmGKB; PA134977227; -.
DR eggNOG; ENOG502TE2A; Eukaryota.
DR HOGENOM; CLU_177416_0_0_1; -.
DR InParanoid; Q6RVD6; -.
DR PhylomeDB; Q6RVD6; -.
DR TreeFam; TF341258; -.
DR PathwayCommons; Q6RVD6; -.
DR SignaLink; Q6RVD6; -.
DR BioGRID-ORCS; 145946; 10 hits in 1059 CRISPR screens.
DR ChiTaRS; SPATA8; human.
DR GenomeRNAi; 145946; -.
DR Pharos; Q6RVD6; Tdark.
DR PRO; PR:Q6RVD6; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q6RVD6; protein.
DR Genevisible; Q6RVD6; HS.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..105
FT /note="Spermatogenesis-associated protein 8"
FT /id="PRO_0000278444"
FT VAR_SEQ 31..105
FT /note="TSSRHFSEAMTCPCGWRPFKGGPGGLKGPVWPAKEENSCSHGRIQRVQRRRV
FT PSASPLIQKINRRSVLFHPYCWS -> YLMSCPWQFSTPDVGLTPIRLPFLCGKTGMKL
FT QHS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023281"
SQ SEQUENCE 105 AA; 11727 MW; 4ED05B470B35E9F1 CRC64;
MAPAGMSGAQ DNSCLYQEIA PSFQRLPCPR TSSRHFSEAM TCPCGWRPFK GGPGGLKGPV
WPAKEENSCS HGRIQRVQRR RVPSASPLIQ KINRRSVLFH PYCWS
