SPAT9_MOUSE
ID SPAT9_MOUSE Reviewed; 252 AA.
AC Q9D9R3; Q9D4M8;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Spermatogenesis-associated protein 9;
GN Name=Spata9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP DEVELOPMENTAL STAGE.
RC TISSUE=Testis;
RX PubMed=12493713; DOI=10.1095/biolreprod.102.004242;
RA Cheng L.J., Li J.M., Chen J., Ge Y.H., Yu Z.R., Han D.S., Zhou Z.M.,
RA Sha J.H.;
RT "NYD-SP16, a novel gene associated with spermatogenesis of human testis.";
RL Biol. Reprod. 68:190-198(2003).
CC -!- FUNCTION: May play at role in testicular development/spermatogenesis
CC and may be an important factor in male infertility. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D9R3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D9R3-2; Sequence=VSP_023285, VSP_023286;
CC -!- DEVELOPMENTAL STAGE: In the 7-week-old, expressed in spermatogenic
CC cells at every stage, (spermatogonium, primary spermatocyte, spermatid,
CC and mature sperm). Expression levels increased during spermatogenesis.
CC No expression in Leydig cells. {ECO:0000269|PubMed:12493713}.
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DR EMBL; AK006554; BAB24651.1; -; mRNA.
DR EMBL; AK016416; BAB30221.1; -; mRNA.
DR EMBL; BC048558; AAH48558.1; -; mRNA.
DR CCDS; CCDS26653.1; -. [Q9D9R3-1]
DR RefSeq; NP_083619.1; NM_029343.3. [Q9D9R3-1]
DR RefSeq; XP_006517505.1; XM_006517442.2. [Q9D9R3-1]
DR RefSeq; XP_006517506.1; XM_006517443.3. [Q9D9R3-1]
DR RefSeq; XP_017171114.1; XM_017315625.1. [Q9D9R3-2]
DR AlphaFoldDB; Q9D9R3; -.
DR STRING; 10090.ENSMUSP00000022081; -.
DR PhosphoSitePlus; Q9D9R3; -.
DR PaxDb; Q9D9R3; -.
DR PRIDE; Q9D9R3; -.
DR ProteomicsDB; 261491; -. [Q9D9R3-1]
DR ProteomicsDB; 261492; -. [Q9D9R3-2]
DR Antibodypedia; 2732; 56 antibodies from 16 providers.
DR DNASU; 75571; -.
DR Ensembl; ENSMUST00000022081; ENSMUSP00000022081; ENSMUSG00000021590. [Q9D9R3-1]
DR GeneID; 75571; -.
DR KEGG; mmu:75571; -.
DR UCSC; uc007rgb.1; mouse. [Q9D9R3-1]
DR CTD; 83890; -.
DR MGI; MGI:1922821; Spata9.
DR VEuPathDB; HostDB:ENSMUSG00000021590; -.
DR eggNOG; ENOG502SNFZ; Eukaryota.
DR GeneTree; ENSGT00390000014160; -.
DR HOGENOM; CLU_097205_0_0_1; -.
DR InParanoid; Q9D9R3; -.
DR OMA; MFPEGEI; -.
DR OrthoDB; 1429836at2759; -.
DR PhylomeDB; Q9D9R3; -.
DR TreeFam; TF338769; -.
DR BioGRID-ORCS; 75571; 4 hits in 73 CRISPR screens.
DR PRO; PR:Q9D9R3; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9D9R3; protein.
DR Bgee; ENSMUSG00000021590; Expressed in spermatid and 60 other tissues.
DR ExpressionAtlas; Q9D9R3; baseline and differential.
DR Genevisible; Q9D9R3; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR031659; SPATA9.
DR PANTHER; PTHR35669; PTHR35669; 1.
DR Pfam; PF15824; SPATA9; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Developmental protein; Differentiation; Membrane;
KW Reference proteome; Spermatogenesis; Transmembrane; Transmembrane helix.
FT CHAIN 1..252
FT /note="Spermatogenesis-associated protein 9"
FT /id="PRO_0000278447"
FT TRANSMEM 145..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 208..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 127..142
FT /note="MKRGSLFEIISFPAKT -> AQETSWGQDRRPEEML (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_023285"
FT VAR_SEQ 143..252
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_023286"
SQ SEQUENCE 252 AA; 28482 MW; FB282ED4DD187F06 CRC64;
MEVRPIGWIC GQVVKNFSGR LEGLQKAIMD LIDEFKDDLP TILRLSQSSQ KTDPVQKTSK
VRMALALAKI NRGTLIQGLN HISSSSKSVA KLLQPRLAYR LLELRSISHR LLREVNVASQ
PLHSVQMKRG SLFEIISFPA KTALTSIMYA SYAALIYLAV CVNAVLAKIK KIFQEEESIR
QNRESENFRK AFSEPALRKP MFSESEIKAK PYRSLPEKPD NLLDQPKPPA NKQSNKIQVL
HSVFDQLAEL NE
