ID   SPB10_BOVIN             Reviewed;         397 AA.
AC   A5PJK0;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Serpin B10;
GN   Name=SERPINB10;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protease inhibitor that may play a role in the regulation of
CC       protease activities during hematopoiesis and apoptosis induced by TNF.
CC       May regulate protease activities in the cytoplasm and in the nucleus
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the serpin family. Ov-serpin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC142142; AAI42143.1; -; mRNA.
DR   RefSeq; NP_001092395.1; NM_001098925.1.
DR   AlphaFoldDB; A5PJK0; -.
DR   SMR; A5PJK0; -.
DR   STRING; 9913.ENSBTAP00000001458; -.
DR   MEROPS; I04.015; -.
DR   PaxDb; A5PJK0; -.
DR   PRIDE; A5PJK0; -.
DR   Ensembl; ENSBTAT00000001458; ENSBTAP00000001458; ENSBTAG00000001102.
DR   GeneID; 510205; -.
DR   KEGG; bta:510205; -.
DR   CTD; 5273; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001102; -.
DR   VGNC; VGNC:56372; SERPINB10.
DR   eggNOG; KOG2392; Eukaryota.
DR   GeneTree; ENSGT00940000161205; -.
DR   HOGENOM; CLU_023330_0_2_1; -.
DR   InParanoid; A5PJK0; -.
DR   OMA; QFNRDQD; -.
DR   OrthoDB; 1124079at2759; -.
DR   TreeFam; TF352619; -.
DR   Reactome; R-BTA-6798695; Neutrophil degranulation.
DR   Proteomes; UP000009136; Chromosome 24.
DR   Bgee; ENSBTAG00000001102; Expressed in ruminant reticulum and 31 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Protease inhibitor; Reference proteome;
KW   Serine protease inhibitor.
FT   CHAIN           1..397
FT                   /note="Serpin B10"
FT                   /id="PRO_0000355544"
FT   MOTIF           74..77
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   SITE            362..363
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   397 AA;  45196 MW;  0F775DE1DC59C099 CRC64;
     MDFLAKSINQ FALEFSKKLA ESAEGKNIFF SPWGISASLA MVYLGTKGTT AAQMAQVLQF
     SRDQDSKFCP DSEKKRKMEF NVGKPEEIYS DFQTLISEIN SSSHACILKT ANRIYGEKTF
     PFHKKYLEDV KTYFGAEPQS VNFIGASDQI RKEINSWVEK QTEGKILNLL PDDAVDPTTR
     MVLVNALYFK GVWEHQFLVQ NTTEKSFKIN KTTSKPVQMM SMKEKLQVFY IESPQAMGLQ
     LYYESRDLSL LILLPEDVDG LDQLEKTITY EKLSEWTSAD MMELCNVQLN LPKFKLEETY
     DLKSTLSSMG MSDAFNQSKA DFSGMSSERN LFLSNVFHKC FVEINEQGTE AAAGTGSEVS
     VRMKLPSIEF NADHPFLFFI RHNKTNGILF YGRFCSP