ID   SPB10_CALJA             Reviewed;         397 AA.
AC   B0CMB0;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Serpin B10;
GN   Name=SERPINB10;
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Antonellis A., Ayele K., Benjamin B., Blakesley R.W., Boakye A.,
RA   Bouffard G.G., Brinkley C., Brooks S., Chu G., Coleman H., Engle J.,
RA   Gestole M., Greene A., Guan X., Gupta J., Haghighi P., Han J., Hansen N.,
RA   Ho S.-L., Hu P., Hunter G., Hurle B., Idol J.R., Kwong P., Laric P.,
RA   Larson S., Lee-Lin S.-Q., Legaspi R., Madden M., Maduro Q.L., Maduro V.B.,
RA   Margulies E.H., Masiello C., Maskeri B., McDowell J., Mojidi H.A.,
RA   Mullikin J.C., Oestreicher J.S., Park M., Portnoy M.E., Prasad A., Puri O.,
RA   Reddix-Dugue N., Schandler K., Schueler M.G., Sison C., Stantripop S.,
RA   Stephen E., Taye A., Thomas J.W., Thomas P.J., Tsipouri V., Ung L.,
RA   Vogt J.L., Wetherby K.D., Young A., Green E.D.;
RT   "NISC comparative sequencing initiative.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protease inhibitor that may play a role in the regulation of
CC       protease activities during hematopoiesis and apoptosis induced by TNF.
CC       May regulate protease activities in the cytoplasm and in the nucleus
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the serpin family. Ov-serpin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DP000562; ABY74571.1; -; Genomic_DNA.
DR   RefSeq; XP_008978187.1; XM_008979939.2.
DR   AlphaFoldDB; B0CMB0; -.
DR   SMR; B0CMB0; -.
DR   STRING; 9483.ENSCJAP00000012445; -.
DR   MEROPS; I04.015; -.
DR   PRIDE; B0CMB0; -.
DR   GeneID; 100407965; -.
DR   KEGG; cjc:100407965; -.
DR   CTD; 5273; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   HOGENOM; CLU_023330_0_2_1; -.
DR   InParanoid; B0CMB0; -.
DR   OrthoDB; 1124079at2759; -.
DR   TreeFam; TF352619; -.
DR   Proteomes; UP000008225; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protease inhibitor; Reference proteome;
KW   Serine protease inhibitor.
FT   CHAIN           1..397
FT                   /note="Serpin B10"
FT                   /id="PRO_0000355545"
FT   MOTIF           74..77
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   SITE            362..363
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   397 AA;  45433 MW;  F3DB5E81CDBB68E5 CRC64;
     MDALATSINQ FALELSQKLA ESAQGKNIFF SAWSISASLA MVHLGAKGNT AAQMAQVLQF
     KRDQGVKSDP ESEKKRKMEF NLSNSGEIHC NFQTLISEIL KPNNDYILKT ANATYSEKTY
     PFHNKYLEDV KTYFGAEPQS VNFVEASDQI RKEINSWVER QTEGKIQNLL SDDSVDSTTR
     MVLVNALYFK GIWEHQFLVQ HTTEKPFRIN ETTSKPVQMM FMKEKLQIFH IEKPQALGLQ
     LYYKSRDLSL FILLPEDING LEQLEKAITY EKLNEWTSAD MMEVYHVQLH LPKFKLEESY
     DLKSTLSSMG MRDAFSESKA DFSGMSSARN LFLSNVFHKA FVEIDEQGTE AAAGSGSEIS
     FRMKVPSIEF NANHPFLFFI RHNKTNNILF YGRFCSP