ID   SPB10_OTOGA             Reviewed;         397 AA.
AC   B4USX2;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 40.
DE   RecName: Full=Serpin B10;
GN   Name=SERPINB10;
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii(Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protease inhibitor that may play a role in the regulation of
CC       protease activities during hematopoiesis and apoptosis induced by TNF.
CC       May regulate protease activities in the cytoplasm and in the nucleus
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the serpin family. Ov-serpin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DP000877; ACG64313.1; -; Genomic_DNA.
DR   AlphaFoldDB; B4USX2; -.
DR   SMR; B4USX2; -.
DR   STRING; 30611.ENSOGAP00000014912; -.
DR   MEROPS; I04.015; -.
DR   PRIDE; B4USX2; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   InParanoid; B4USX2; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protease inhibitor; Reference proteome;
KW   Serine protease inhibitor.
FT   CHAIN           1..397
FT                   /note="Serpin B10"
FT                   /id="PRO_0000355547"
FT   MOTIF           74..77
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   SITE            362..363
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   397 AA;  45124 MW;  F726DDCA5756D556 CRC64;
     MDPLASSISQ FALEFSKELA ASAAGKNIFF SPWSISSALA MVYLGARGTT AVEMAKVLQL
     NRDQADKTGP ESEKKRKMEF NLGKAEEIHC DFQTLISEIL KPTDAHVLKT ANGIYGEKTY
     PFHNKYLEEV KTYFGAEPQS VNFVEASDQI RKEINSWVES QTQGKILNLL PDDSVDSTTR
     MILVNALYFK GTWEHQFLAQ NTTEKPFRIN ETTSKPVQMM SMKEKLHVFH IEKPQATGLQ
     LYYERRDVSL FILLPEDLGG LEQLEKAITY EKLNEWTSAD MMELYDVQLS LPKFKLEESY
     DLKSTLSSMG MSDAFNPSKA DFSGMSLERN LYLSNIFHKV FVEINEEGTE AAAGTGSEVG
     FRIKYPSIEF NVDHPFLFFI RHNKTNSILF YGRFCSP