SPB11_MOUSE
ID SPB11_MOUSE Reviewed; 388 AA.
AC Q9CQV3; Q91Z12;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Serpin B11;
GN Name=Serpinb11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Lung;
RX PubMed=15203215; DOI=10.1016/j.ygeno.2004.01.015;
RA Askew D.J., Askew Y.S., Kato Y., Turner R.F., Dewar K., Lehoczky J.,
RA Silverman G.A.;
RT "Comparative genomic analysis of the clade B serpin cluster at human
RT chromosome 18q21: amplification within the mouse squamous cell carcinoma
RT antigen gene locus.";
RL Genomics 84:176-184(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, AND REACTIVE BOND.
RX PubMed=17562709; DOI=10.1074/jbc.m703182200;
RA Askew D.J., Cataltepe S., Kumar V., Edwards C., Pace S.M., Howarth R.N.,
RA Pak S.C., Askew Y.S., Bromme D., Luke C.J., Whisstock J.C., Silverman G.A.;
RT "SERPINB11 is a new noninhibitory intracellular serpin. Common single
RT nucleotide polymorphisms in the scaffold impair conformational change.";
RL J. Biol. Chem. 282:24948-24960(2007).
CC -!- FUNCTION: Inhibitor of serine proteases. Has moderate inhibitory
CC activity for trypsin-like peptidases, but also some activity with
CC cysteine peptidases, cathepsin L, K, and V, and the serine peptidase,
CC tryptase gamma. {ECO:0000269|PubMed:17562709}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in eye, lung, lymphocytes, thymus,
CC stomach, uterus, heart, brain, liver, skeletal muscle, and in day 7,
CC 15, and 17 embryos. {ECO:0000269|PubMed:17562709}.
CC -!- SIMILARITY: Belongs to the serpin family. Ov-serpin subfamily.
CC {ECO:0000305}.
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DR EMBL; AY367772; AAR89286.1; -; mRNA.
DR EMBL; AK009003; BAB26017.1; -; mRNA.
DR EMBL; AK009855; BAB26546.1; -; mRNA.
DR EMBL; BC010313; AAH10313.1; -; mRNA.
DR CCDS; CCDS15218.1; -.
DR RefSeq; NP_080143.1; NM_025867.2.
DR AlphaFoldDB; Q9CQV3; -.
DR SMR; Q9CQV3; -.
DR STRING; 10090.ENSMUSP00000027566; -.
DR PhosphoSitePlus; Q9CQV3; -.
DR MaxQB; Q9CQV3; -.
DR PaxDb; Q9CQV3; -.
DR PRIDE; Q9CQV3; -.
DR ProteomicsDB; 258715; -.
DR Antibodypedia; 23130; 131 antibodies from 20 providers.
DR DNASU; 66957; -.
DR Ensembl; ENSMUST00000027566; ENSMUSP00000027566; ENSMUSG00000026327.
DR GeneID; 66957; -.
DR KEGG; mmu:66957; -.
DR UCSC; uc007chl.1; mouse.
DR CTD; 89778; -.
DR MGI; MGI:1914207; Serpinb11.
DR VEuPathDB; HostDB:ENSMUSG00000026327; -.
DR eggNOG; KOG2392; Eukaryota.
DR GeneTree; ENSGT00940000161560; -.
DR HOGENOM; CLU_023330_0_2_1; -.
DR InParanoid; Q9CQV3; -.
DR OMA; PSNMVER; -.
DR OrthoDB; 1124079at2759; -.
DR PhylomeDB; Q9CQV3; -.
DR TreeFam; TF352619; -.
DR BioGRID-ORCS; 66957; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q9CQV3; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9CQV3; protein.
DR Bgee; ENSMUSG00000026327; Expressed in nasal cavity epithelium and 72 other tissues.
DR ExpressionAtlas; Q9CQV3; baseline and differential.
DR Genevisible; Q9CQV3; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central.
DR Gene3D; 2.30.39.10; -; 1.
DR Gene3D; 3.30.497.10; -; 1.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461; PTHR11461; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; SSF56574; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Protease inhibitor; Reference proteome;
KW Serine protease inhibitor.
FT CHAIN 1..388
FT /note="Serpin B11"
FT /id="PRO_0000094118"
FT REGION 338..362
FT /note="RCL"
FT /evidence="ECO:0000250"
FT SITE 354..355
FT /note="Reactive bond"
FT CONFLICT 82
FT /note="V -> M (in Ref. 3; AAH10313)"
FT /evidence="ECO:0000305"
FT CONFLICT 207
FT /note="A -> T (in Ref. 3; AAH10313)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 388 AA; 43482 MW; 533D882BF58F09AE CRC64;
MDPITTASTE FCLDVFKELS SNNVGENIFF SPLTTFYALS MLLLGTRGKS AEQMEKVLHY
DSFSGVLKAK TKNSSECSQV GVMHPDFRAL ISHINQQNSL SVANRIYGTR SISFHKQYVR
CCEKLYQAKL QTVDFELSTE ETRKSINAWV KNKTNGKITN LFAKGTIDPS SVMVLVSAIY
FKGQWQNKFQ KRETVKAPFH MGVGKSAVVN MMYQTGTFKL AIIKEPEMQV LELPYANNKL
RMIILLPVGT ASVSQIEKHL NVKMLREWTN PSNMVEREVD VHIPKFSLSV KYDLNTLLKS
LGMRDIFNVA NADLSGMSPD KGLYLSKVVH KSYVDVNEEG TEAAAATGES ISVKRLPVTV
QFTANCPFLF FIWDESGNIL FAGKFASP
