SPB13_MOUSE
ID SPB13_MOUSE Reviewed; 389 AA.
AC Q8CDC0; Q148S5; Q148S6;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Serpin B13;
GN Name=Serpinb13;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in the proliferation or differentiation of
CC keratinocytes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CDC0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CDC0-2; Sequence=VSP_039855;
CC -!- SIMILARITY: Belongs to the serpin family. Ov-serpin subfamily.
CC {ECO:0000305}.
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DR EMBL; AK030670; BAC27072.1; -; mRNA.
DR EMBL; CH466520; EDL39854.1; -; Genomic_DNA.
DR EMBL; BC117990; AAI17991.1; -; mRNA.
DR EMBL; BC117991; AAI17992.1; -; mRNA.
DR CCDS; CCDS15213.1; -. [Q8CDC0-1]
DR RefSeq; NP_766440.2; NM_172852.3. [Q8CDC0-1]
DR AlphaFoldDB; Q8CDC0; -.
DR SMR; Q8CDC0; -.
DR STRING; 10090.ENSMUSP00000027564; -.
DR MEROPS; I04.017; -.
DR iPTMnet; Q8CDC0; -.
DR PhosphoSitePlus; Q8CDC0; -.
DR PaxDb; Q8CDC0; -.
DR PeptideAtlas; Q8CDC0; -.
DR PRIDE; Q8CDC0; -.
DR ProteomicsDB; 261494; -. [Q8CDC0-1]
DR ProteomicsDB; 261495; -. [Q8CDC0-2]
DR Antibodypedia; 10046; 230 antibodies from 28 providers.
DR DNASU; 241196; -.
DR Ensembl; ENSMUST00000027564; ENSMUSP00000027564; ENSMUSG00000048775. [Q8CDC0-1]
DR GeneID; 241196; -.
DR KEGG; mmu:241196; -.
DR UCSC; uc007chf.1; mouse. [Q8CDC0-1]
DR UCSC; uc011wqd.1; mouse. [Q8CDC0-2]
DR CTD; 5275; -.
DR MGI; MGI:3042250; Serpinb13.
DR VEuPathDB; HostDB:ENSMUSG00000048775; -.
DR eggNOG; KOG2392; Eukaryota.
DR GeneTree; ENSGT00940000162214; -.
DR HOGENOM; CLU_023330_0_2_1; -.
DR InParanoid; Q8CDC0; -.
DR OMA; IHHQFQK; -.
DR OrthoDB; 1124079at2759; -.
DR PhylomeDB; Q8CDC0; -.
DR TreeFam; TF352619; -.
DR Reactome; R-MMU-8939242; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes.
DR BioGRID-ORCS; 241196; 3 hits in 74 CRISPR screens.
DR PRO; PR:Q8CDC0; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8CDC0; protein.
DR Bgee; ENSMUSG00000048775; Expressed in esophagus and 3 other tissues.
DR ExpressionAtlas; Q8CDC0; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; ISO:MGI.
DR GO; GO:0002020; F:protease binding; ISO:MGI.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0010951; P:negative regulation of endopeptidase activity; ISO:MGI.
DR GO; GO:1902173; P:negative regulation of keratinocyte apoptotic process; ISO:MGI.
DR Gene3D; 2.30.39.10; -; 1.
DR Gene3D; 3.30.497.10; -; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461; PTHR11461; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; SSF56574; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Protease inhibitor; Reference proteome;
KW Serine protease inhibitor.
FT CHAIN 1..389
FT /note="Serpin B13"
FT /id="PRO_0000094122"
FT SITE 354..355
FT /note="Reactive bond"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..211
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039855"
FT CONFLICT 295
FT /note="L -> Q (in Ref. 1; BAC27072)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 389 AA; 44316 MW; B2960B949EA5EFD9 CRC64;
MDSLGTAATQ FLFDLFKELN KTNDGNVFFS PVGISTAIGM IILGTRGATA SELQKVLYTE
QGTESSRIKS EEEEIEKREE IHHQLQMLLT EISKFSNDYD LIISNRLFGE KTYLFLQKYI
DYVEKYYHAS LEPVDFVNAA DESRKKINSW VESQTNVKVK DLFPEGSLNS STKLVLINTV
YFKGLWDREF KKEHTKEEDF WLNKNLSKPV QMMALCSSFN FTFLEDLQAK IVGIPYKNND
ISMFVLLPND IDGLEKIMDK MSPEKLVEWT SPGHLEQRRV DLRLPRLQVE ETYDLEPVLE
AVGIHSAFSE HADYSGMSAR SGLHAQNFLH RSFLVVTEEG VEATAGTGVG LKVSSAASCE
LVHCNHPFLF FIRHRESDSI LFFGKFSSP
