ID   SPB6_BOVIN              Reviewed;         378 AA.
AC   O02739; A5PK82;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Serpin B6;
DE   AltName: Full=Proteinase inhibitor 6;
DE   AltName: Full=Serine proteinase inhibitor B-43;
GN   Name=SERPINB6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=9013786; DOI=10.1016/s0169-328x(96)00133-7;
RA   Nakaya N., Nishibori M., Kawabata M., Saeki K.;
RT   "Cloning of a serine proteinase inhibitor from bovine brain: expression in
RT   the brain and characterization of its target proteinases.";
RL   Brain Res. Mol. Brain Res. 42:293-300(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal lung;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play
CC       an important role in the inner ear in the protection against leakage of
CC       lysosomal content during stress (By similarity). May be involved in the
CC       regulation of serine proteinases present in the brain or extravasated
CC       from the blood. {ECO:0000250}.
CC   -!- SUBUNIT: Forms a complex with the monomeric form of beta-tryptase.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Brain.
CC   -!- SIMILARITY: Belongs to the serpin family. Ov-serpin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; D55670; BAA19875.1; -; mRNA.
DR   EMBL; BC142394; AAI42395.1; -; mRNA.
DR   RefSeq; NP_777214.1; NM_174789.1.
DR   AlphaFoldDB; O02739; -.
DR   SMR; O02739; -.
DR   STRING; 9913.ENSBTAP00000026816; -.
DR   PeptideAtlas; O02739; -.
DR   PRIDE; O02739; -.
DR   GeneID; 286854; -.
DR   KEGG; bta:286854; -.
DR   CTD; 5269; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   InParanoid; O02739; -.
DR   OrthoDB; 1124079at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Protease inhibitor; Reference proteome;
KW   Serine protease inhibitor.
FT   CHAIN           1..378
FT                   /note="Serpin B6"
FT                   /id="PRO_0000094105"
FT   SITE            343..344
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:P35237"
FT   MOD_RES         196
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q60854"
SQ   SEQUENCE   378 AA;  42561 MW;  664F499CCFCE263A CRC64;
     MDALSEANGT FALTLLKKLG EGNSKNVFIS PLSISSALAM VLLGAKGNTA AQMCQTLSLN
     KSSGGGEDVH QGFQNLLSEV NRRDTQYLLR TANRLFGEKT YDFLSSFKDS CHKFYQAEME
     ELDFVSATEQ SRKHINTWVA EKTEGKIRDL LPANSVNPMT RLVLVNAIYF KGNWDTQFNK
     EHTEERPFRV SKNVEKPVQM MFKKSTCKIT YIGEISTQIL VLPYVGQELN MVILLPSEST
     DLNTVEKALT YEKFIAWTKP DVMDEEEVEV FLPRFTLEES YDMEEFLQEL GMTDAFEETR
     ADFSGMSSGR GLHLSKVMHK SFVEVTEEGT EAAAATGAVV MMRCLMVVPR FNANHPFLFF
     IQHSKTGAIL FCGRFCSP