SPB8_MOUSE
ID SPB8_MOUSE Reviewed; 374 AA.
AC O08800;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Serpin B8;
GN Name=Serpinb8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=FVB/N;
RX PubMed=11863365; DOI=10.1006/geno.2002.6716;
RA Kaiserman D., Knaggs S., Scarff K.L., Gillard A., Mirza G., Cadman M.,
RA McKeone R., Denny P., Cooley J., Benarafa C., Remold-O'Donnell E.,
RA Ragoussis J., Bird P.I.;
RT "Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a
RT greatly expanded ov-serpin gene repertoire in the mouse.";
RL Genomics 79:349-362(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Vagina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Lung, and Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Has an important role in epithelial desmosome-mediated cell-
CC cell adhesion. {ECO:0000250|UniProtKB:P50452}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the serpin family. Ov-serpin subfamily.
CC {ECO:0000305}.
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DR EMBL; U96703; AAB57815.2; -; mRNA.
DR EMBL; AK036811; BAC29588.1; -; mRNA.
DR EMBL; BC025121; AAH25121.1; -; mRNA.
DR CCDS; CCDS15220.1; -.
DR RefSeq; NP_035589.1; NM_011459.4.
DR AlphaFoldDB; O08800; -.
DR SMR; O08800; -.
DR STRING; 10090.ENSMUSP00000108326; -.
DR MEROPS; I04.013; -.
DR iPTMnet; O08800; -.
DR PhosphoSitePlus; O08800; -.
DR MaxQB; O08800; -.
DR PaxDb; O08800; -.
DR PeptideAtlas; O08800; -.
DR PRIDE; O08800; -.
DR ProteomicsDB; 263313; -.
DR Antibodypedia; 23169; 307 antibodies from 31 providers.
DR DNASU; 20725; -.
DR Ensembl; ENSMUST00000000514; ENSMUSP00000000514; ENSMUSG00000026315.
DR Ensembl; ENSMUST00000112706; ENSMUSP00000108326; ENSMUSG00000026315.
DR GeneID; 20725; -.
DR KEGG; mmu:20725; -.
DR UCSC; uc007chs.2; mouse.
DR CTD; 5271; -.
DR MGI; MGI:894657; Serpinb8.
DR VEuPathDB; HostDB:ENSMUSG00000026315; -.
DR eggNOG; KOG2392; Eukaryota.
DR GeneTree; ENSGT00940000154835; -.
DR HOGENOM; CLU_023330_0_2_1; -.
DR InParanoid; O08800; -.
DR OMA; NCIFFCG; -.
DR OrthoDB; 1124079at2759; -.
DR PhylomeDB; O08800; -.
DR TreeFam; TF352619; -.
DR Reactome; R-MMU-75205; Dissolution of Fibrin Clot.
DR BioGRID-ORCS; 20725; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Serpinb8; mouse.
DR PRO; PR:O08800; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; O08800; protein.
DR Bgee; ENSMUSG00000026315; Expressed in lumbar dorsal root ganglion and 97 other tissues.
DR ExpressionAtlas; O08800; baseline and differential.
DR Genevisible; O08800; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; ISO:MGI.
DR GO; GO:0090136; P:epithelial cell-cell adhesion; ISO:MGI.
DR GO; GO:0010951; P:negative regulation of endopeptidase activity; ISO:MGI.
DR Gene3D; 2.30.39.10; -; 1.
DR Gene3D; 3.30.497.10; -; 1.
DR InterPro; IPR000240; Serpin_B9/Maspin.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461; PTHR11461; 1.
DR Pfam; PF00079; Serpin; 1.
DR PRINTS; PR00676; MASPIN.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; SSF56574; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Protease inhibitor; Reference proteome;
KW Serine protease inhibitor.
FT CHAIN 1..374
FT /note="Serpin B8"
FT /id="PRO_0000094112"
FT SITE 339..340
FT /note="Reactive bond"
FT /evidence="ECO:0000250"
SQ SEQUENCE 374 AA; 42150 MW; F8B2ABB47AA47378 CRC64;
MDDLSEANGS FAISLLKILS EKDKSRNLFF CPMSVSSALA MVYLGAKGNT ATQMSEVLGL
SGNGDVHQSF QTLLAEINKT DTQYLLKSAC RLFGEESCDF LSTFKESCHK FYQAGLEELS
FAKDTEGCRK HINDWVSEKT EGKISEVLSP GTVCPLTKLV LVNAMYFKGK WKAQFDRKYT
RGMPFKTNQE KKTVQMMFKH AKFKMGHVDE VNMQVLALPY AEEELSMVIL LPDESTDLAV
VEKALTYEKL RAWTNPETLT ESQVQVFLPR LKLEESYDLE TVLQNLGMTD AFEETRADFS
GMTTKKNVPV SKVAHKCFVE VNEEGTEAAA ATAVIRNARC CRTEPRFCAD HPFLFFIWHH
KTSSILFCGR FSSP
