SPBP_MOUSE
ID SPBP_MOUSE Reviewed; 199 AA.
AC P15501;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Prostatic spermine-binding protein;
DE Short=SBP;
DE AltName: Full=Major prostatic secretory glycoprotein;
DE AltName: Full=P25;
DE Flags: Precursor;
GN Name=Sbp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC TISSUE=Prostate;
RX PubMed=3502715; DOI=10.1093/nar/15.19.7709;
RA Mills J.S., Needham M., Parker M.G.;
RT "Androgen regulated expression of a spermine binding protein gene in mouse
RT ventral prostate.";
RL Nucleic Acids Res. 15:7709-7724(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: This protein seems to be functional equivalent to rat
CC prostatic spermine-binding protein, which is involved in polyamine
CC binding.
CC -!- TISSUE SPECIFICITY: Prostate.
CC -!- INDUCTION: By androgens.
CC -!- SIMILARITY: To rat SBP. {ECO:0000305}.
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DR EMBL; X06246; CAA29591.1; -; mRNA.
DR EMBL; X06248; CAA29592.1; -; Genomic_DNA.
DR EMBL; X06249; CAA29592.1; JOINED; Genomic_DNA.
DR EMBL; X06250; CAA29592.1; JOINED; Genomic_DNA.
DR EMBL; BC049605; AAH49605.1; -; mRNA.
DR CCDS; CCDS57056.1; -.
DR PIR; S01266; S01266.
DR RefSeq; NP_035451.1; NM_011321.3.
DR AlphaFoldDB; P15501; -.
DR SMR; P15501; -.
DR STRING; 10090.ENSMUSP00000138219; -.
DR GlyGen; P15501; 1 site.
DR iPTMnet; P15501; -.
DR PhosphoSitePlus; P15501; -.
DR PaxDb; P15501; -.
DR PRIDE; P15501; -.
DR ProteomicsDB; 263314; -.
DR DNASU; 20234; -.
DR Ensembl; ENSMUST00000024940; ENSMUSP00000024940; ENSMUSG00000024128.
DR Ensembl; ENSMUST00000181985; ENSMUSP00000138422; ENSMUSG00000024128.
DR Ensembl; ENSMUST00000183155; ENSMUSP00000138341; ENSMUSG00000024128.
DR Ensembl; ENSMUST00000183252; ENSMUSP00000138219; ENSMUSG00000024128.
DR GeneID; 20234; -.
DR KEGG; mmu:20234; -.
DR UCSC; uc008auc.1; mouse.
DR CTD; 20234; -.
DR MGI; MGI:106021; Sbp.
DR VEuPathDB; HostDB:ENSMUSG00000024128; -.
DR eggNOG; ENOG502SWMW; Eukaryota.
DR GeneTree; ENSGT00940000166063; -.
DR InParanoid; P15501; -.
DR OMA; CIRYLEI; -.
DR OrthoDB; 1317341at2759; -.
DR PhylomeDB; P15501; -.
DR TreeFam; TF333440; -.
DR BioGRID-ORCS; 20234; 11 hits in 70 CRISPR screens.
DR ChiTaRS; Sbp; mouse.
DR PRO; PR:P15501; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; P15501; protein.
DR Bgee; ENSMUSG00000024128; Expressed in morula and 7 other tissues.
DR ExpressionAtlas; P15501; differential.
DR Genevisible; P15501; MM.
DR GO; GO:0005576; C:extracellular region; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR Gene3D; 2.100.10.30; -; 1.
DR InterPro; IPR001229; Jacalin-like_lectin_dom.
DR InterPro; IPR036404; Jacalin-like_lectin_dom_sf.
DR Pfam; PF01419; Jacalin; 1.
DR SMART; SM00915; Jacalin; 1.
DR SUPFAM; SSF51101; SSF51101; 1.
DR PROSITE; PS51752; JACALIN_LECTIN; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Lectin; Reference proteome; Signal.
FT SIGNAL 1..18
FT CHAIN 19..199
FT /note="Prostatic spermine-binding protein"
FT /id="PRO_0000022389"
FT DOMAIN 19..151
FT /note="Jacalin-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01088"
FT REGION 159..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..199
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 199 AA; 21966 MW; 2DFD460803A8BDDD CRC64;
MLLLLTLAFL ASPTCRAQNV LGNAAGKYFY VQGEDQGQLK GMRIFLSVFK FIKGFQLQFG
SNWTDVYGTR SDNFIDFLLE DGEHVIKVEG SAVICLTSLT FTTNKGRVAT FGVRRGRYFS
DTGGSDKHLV TVNGMHAPGL CVRGIGFKWG NINANGNDHY NNKEDKADNK DADNKDADNK
DDGDEDDDGN DDDDQKDES
