SPC19_CANAL
ID SPC19_CANAL Reviewed; 175 AA.
AC Q59QH6; A0A1D8PD66;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=DASH complex subunit SPC19;
DE AltName: Full=Outer kinetochore protein SPC19;
GN Name=SPC19; OrderedLocusNames=CAALFM_C103980WA;
GN ORFNames=CaO19.11953, CaO19.4473;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Component of the DASH complex, a microtubule-binding
CC subcomplex of the outer kinetochore that is essential for proper
CC chromosome segregation. The DASH complex mediates the formation and
CC maintenance of bipolar kinetochore-microtubule attachments by forming
CC closed rings around spindle microtubules and establishing interactions
CC with proteins from the central kinetochore (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: The DASH complex oligomerizes to form rings that encircle the
CC microtubules. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton,
CC spindle {ECO:0000250}. Chromosome, centromere, kinetochore
CC {ECO:0000250}. Note=Associates with the mitotic spindle and the
CC kinetochore. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DASH complex SPC19 family. {ECO:0000305}.
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DR EMBL; CP017623; AOW26073.1; -; Genomic_DNA.
DR RefSeq; XP_711967.2; XM_706874.2.
DR AlphaFoldDB; Q59QH6; -.
DR SMR; Q59QH6; -.
DR BioGRID; 1229516; 1.
DR STRING; 237561.Q59QH6; -.
DR PRIDE; Q59QH6; -.
DR GeneID; 3646423; -.
DR KEGG; cal:CAALFM_C103980WA; -.
DR CGD; CAL0000196840; SPC19.
DR VEuPathDB; FungiDB:C1_03980W_A; -.
DR eggNOG; ENOG502SDEQ; Eukaryota.
DR HOGENOM; CLU_112993_1_0_1; -.
DR InParanoid; Q59QH6; -.
DR OrthoDB; 1586714at2759; -.
DR PRO; PR:Q59QH6; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0042729; C:DASH complex; IBA:GO_Central.
DR GO; GO:0005876; C:spindle microtubule; IEA:InterPro.
DR GO; GO:0008608; P:attachment of spindle microtubules to kinetochore; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR InterPro; IPR013251; DASH_Spc19.
DR PANTHER; PTHR28262; PTHR28262; 1.
DR Pfam; PF08287; DASH_Spc19; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW Coiled coil; Cytoplasm; Cytoskeleton; Kinetochore; Microtubule; Mitosis;
KW Nucleus; Reference proteome.
FT CHAIN 1..175
FT /note="DASH complex subunit SPC19"
FT /id="PRO_0000142587"
FT COILED 70..122
FT /evidence="ECO:0000255"
SQ SEQUENCE 175 AA; 20454 MW; 40A96C3D4876AE23 CRC64;
MTQQDLPQNQ RFNNLDNCTD SLRQSIKILQ QSNKILDETL QDSTRLTKIL STNKVFDLIP
ELDLNDAKSN FTKNITPQLN QQLNKLEDEL IQLQTKKTTL TNKLKLINVR LKNYEKKGNK
EEGGKNFNSN GLSDIDIDNL LTNRHKNGYD VNKLHQLRFL RDKKTRLQYS LNRLN