SPC19_CANGA
ID SPC19_CANGA Reviewed; 154 AA.
AC Q6FU86;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=DASH complex subunit SPC19;
DE AltName: Full=Outer kinetochore protein SPC19;
GN Name=SPC19; OrderedLocusNames=CAGL0F05467g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Component of the DASH complex, a microtubule-binding
CC subcomplex of the outer kinetochore that is essential for proper
CC chromosome segregation. The DASH complex mediates the formation and
CC maintenance of bipolar kinetochore-microtubule attachments by forming
CC closed rings around spindle microtubules and establishing interactions
CC with proteins from the central kinetochore (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: The DASH complex oligomerizes to form rings that encircle the
CC microtubules. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton,
CC spindle {ECO:0000250}. Chromosome, centromere, kinetochore
CC {ECO:0000250}. Note=Associates with the mitotic spindle and the
CC kinetochore. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DASH complex SPC19 family. {ECO:0000305}.
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DR EMBL; CR380952; CAG59132.1; -; Genomic_DNA.
DR RefSeq; XP_446208.1; XM_446208.1.
DR AlphaFoldDB; Q6FU86; -.
DR SMR; Q6FU86; -.
DR STRING; 5478.XP_446208.1; -.
DR EnsemblFungi; CAG59132; CAG59132; CAGL0F05467g.
DR GeneID; 2887932; -.
DR KEGG; cgr:CAGL0F05467g; -.
DR CGD; CAL0131330; CAGL0F05467g.
DR VEuPathDB; FungiDB:CAGL0F05467g; -.
DR eggNOG; ENOG502SDEQ; Eukaryota.
DR HOGENOM; CLU_1678217_0_0_1; -.
DR InParanoid; Q6FU86; -.
DR OMA; YDVQRAK; -.
DR Proteomes; UP000002428; Chromosome F.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0042729; C:DASH complex; IEA:EnsemblFungi.
DR GO; GO:0005876; C:spindle microtubule; IEA:InterPro.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:EnsemblFungi.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:1990758; P:mitotic sister chromatid biorientation; IEA:EnsemblFungi.
DR GO; GO:0051987; P:positive regulation of attachment of spindle microtubules to kinetochore; IEA:EnsemblFungi.
DR GO; GO:0031116; P:positive regulation of microtubule polymerization; IEA:EnsemblFungi.
DR InterPro; IPR013251; DASH_Spc19.
DR PANTHER; PTHR28262; PTHR28262; 1.
DR Pfam; PF08287; DASH_Spc19; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW Coiled coil; Cytoplasm; Cytoskeleton; Kinetochore; Microtubule; Mitosis;
KW Nucleus; Reference proteome.
FT CHAIN 1..154
FT /note="DASH complex subunit SPC19"
FT /id="PRO_0000142588"
FT COILED 72..96
FT /evidence="ECO:0000255"
FT COILED 127..154
FT /evidence="ECO:0000255"
SQ SEQUENCE 154 AA; 17278 MW; 1BFBC55AA8B74E86 CRC64;
MQSLEQCVNS LEAIVHQLDG SVSRLARNGE ASNELCEGIL KIKRVFELVP EYDVESARLA
LFEEVDPMVK TLGDKIEKAL IRKRRELENL RQTSELNSLR LSGDLYFSET GIDNQDMDVS
TDAIAIASAT DAELDELRAL KARRAELQEL LDGR