ID   SPC19_DEBHA             Reviewed;         177 AA.
AC   Q6BHU0;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=DASH complex subunit SPC19;
DE   AltName: Full=Outer kinetochore protein SPC19;
GN   Name=SPC19; OrderedLocusNames=DEHA2G15840g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the DASH complex, a microtubule-binding
CC       subcomplex of the outer kinetochore that is essential for proper
CC       chromosome segregation. The DASH complex mediates the formation and
CC       maintenance of bipolar kinetochore-microtubule attachments by forming
CC       closed rings around spindle microtubules and establishing interactions
CC       with proteins from the central kinetochore (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The DASH complex oligomerizes to form rings that encircle the
CC       microtubules. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       spindle {ECO:0000250}. Chromosome, centromere, kinetochore
CC       {ECO:0000250}. Note=Associates with the mitotic spindle and the
CC       kinetochore. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DASH complex SPC19 family. {ECO:0000305}.
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DR   EMBL; CR382139; CAG90727.2; -; Genomic_DNA.
DR   RefSeq; XP_462231.2; XM_462231.1.
DR   AlphaFoldDB; Q6BHU0; -.
DR   SMR; Q6BHU0; -.
DR   STRING; 4959.XP_462231.2; -.
DR   EnsemblFungi; CAG90727; CAG90727; DEHA2G15840g.
DR   GeneID; 2905155; -.
DR   KEGG; dha:DEHA2G15840g; -.
DR   VEuPathDB; FungiDB:DEHA2G15840g; -.
DR   eggNOG; ENOG502SDEQ; Eukaryota.
DR   HOGENOM; CLU_112993_1_0_1; -.
DR   InParanoid; Q6BHU0; -.
DR   OMA; DCCEEAH; -.
DR   OrthoDB; 1586714at2759; -.
DR   Proteomes; UP000000599; Chromosome G.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0042729; C:DASH complex; IEA:InterPro.
DR   GO; GO:0005876; C:spindle microtubule; IEA:InterPro.
DR   GO; GO:0008608; P:attachment of spindle microtubules to kinetochore; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR013251; DASH_Spc19.
DR   PANTHER; PTHR28262; PTHR28262; 1.
DR   Pfam; PF08287; DASH_Spc19; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Kinetochore; Microtubule; Mitosis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..177
FT                   /note="DASH complex subunit SPC19"
FT                   /id="PRO_0000142589"
FT   COILED          71..107
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   177 AA;  19783 MW;  587B0699C60E9F4B CRC64;
     MSHTYNSLSN CISSLSASVA LLNDSLKTID NATKDIPRLK KVLSTNKVFG LVPESDLESA
     KRNIQNEIQP QINALVIKIE KELSKLKRKK TNLASKVDLQ QVRLENAAKS NRDSLSGIKG
     ITANRISKGD IDESKLARLK LLQNKKERLK YSLSRLNLQD KRARLSTIPS LPPHRDS