SPC19_KLULA
ID SPC19_KLULA Reviewed; 153 AA.
AC Q6CQ94;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=DASH complex subunit SPC19;
DE AltName: Full=Outer kinetochore protein SPC19;
GN Name=SPC19; OrderedLocusNames=KLLA0D18821g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Component of the DASH complex, a microtubule-binding
CC subcomplex of the outer kinetochore that is essential for proper
CC chromosome segregation. The DASH complex mediates the formation and
CC maintenance of bipolar kinetochore-microtubule attachments by forming
CC closed rings around spindle microtubules and establishing interactions
CC with proteins from the central kinetochore (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: The DASH complex oligomerizes to form rings that encircle the
CC microtubules. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton,
CC spindle {ECO:0000250}. Chromosome, centromere, kinetochore
CC {ECO:0000250}. Note=Associates with the mitotic spindle and the
CC kinetochore. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DASH complex SPC19 family. {ECO:0000305}.
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DR EMBL; CR382124; CAH00991.1; -; Genomic_DNA.
DR RefSeq; XP_453895.1; XM_453895.1.
DR AlphaFoldDB; Q6CQ94; -.
DR SMR; Q6CQ94; -.
DR STRING; 28985.XP_453895.1; -.
DR EnsemblFungi; CAH00991; CAH00991; KLLA0_D18821g.
DR GeneID; 2893108; -.
DR KEGG; kla:KLLA0_D18821g; -.
DR eggNOG; ENOG502SDEQ; Eukaryota.
DR HOGENOM; CLU_1678217_0_0_1; -.
DR InParanoid; Q6CQ94; -.
DR OMA; YDVQRAK; -.
DR Proteomes; UP000000598; Chromosome D.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0042729; C:DASH complex; IEA:EnsemblFungi.
DR GO; GO:0005876; C:spindle microtubule; IEA:InterPro.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:EnsemblFungi.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:1990758; P:mitotic sister chromatid biorientation; IEA:EnsemblFungi.
DR GO; GO:0051987; P:positive regulation of attachment of spindle microtubules to kinetochore; IEA:EnsemblFungi.
DR GO; GO:0031116; P:positive regulation of microtubule polymerization; IEA:EnsemblFungi.
DR InterPro; IPR013251; DASH_Spc19.
DR PANTHER; PTHR28262; PTHR28262; 1.
DR Pfam; PF08287; DASH_Spc19; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW Coiled coil; Cytoplasm; Cytoskeleton; Kinetochore; Microtubule; Mitosis;
KW Nucleus; Reference proteome.
FT CHAIN 1..153
FT /note="DASH complex subunit SPC19"
FT /id="PRO_0000142590"
FT COILED 68..153
FT /evidence="ECO:0000255"
SQ SEQUENCE 153 AA; 17772 MW; 2FEB2288801E889A CRC64;
MEEVLSEGVD ALAACVDDMA KCLTVSKVTT DRSTKLAINM LQTKRVFQLV SEYDVQRARL
DLMEDIEPLL QKLYSKLEKA LTKLERERAT LSQTFELNKL RFNNQESNPI IDNVKSDPVV
IVSSTHEELE RLKDLKNRKE ELIQRIQELH EER