ID   SPC19_SCHPO             Reviewed;         152 AA.
AC   Q50HP3;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 2.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=DASH complex subunit spc19;
DE   AltName: Full=Outer kinetochore protein spc19;
GN   Name=spc19; ORFNames=SPCC1223.15c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE, FUNCTION, AND SUBUNIT.
RX   PubMed=16079914; DOI=10.1038/sj.emboj.7600762;
RA   Liu X., McLeod I., Anderson S., Yates J.R. III, He X.;
RT   "Molecular analysis of kinetochore architecture in fission yeast.";
RL   EMBO J. 24:2919-2930(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Component of the DASH complex, a microtubule-binding
CC       subcomplex of the outer kinetochore that is essential for proper
CC       chromosome segregation. The DASH complex mediates the formation and
CC       maintenance of bipolar kinetochore-microtubule attachments by forming
CC       closed rings around spindle microtubules and establishing interactions
CC       with proteins from the central kinetochore. May be necessary for growth
CC       under high osmotic stress. {ECO:0000269|PubMed:16079914}.
CC   -!- SUBUNIT: The DASH complex oligomerizes to form rings that encircle the
CC       microtubules. {ECO:0000269|PubMed:16079914}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       spindle {ECO:0000250}. Chromosome, centromere, kinetochore
CC       {ECO:0000250}. Note=Associates with the mitotic spindle and the
CC       kinetochore. Kinetochore association occurs only during mitosis (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DASH complex SPC19 family. {ECO:0000305}.
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DR   EMBL; CU329672; CAI94399.2; -; Genomic_DNA.
DR   RefSeq; XP_001713170.1; XM_001713118.1.
DR   AlphaFoldDB; Q50HP3; -.
DR   SMR; Q50HP3; -.
DR   BioGRID; 857864; 137.
DR   STRING; 4896.SPCC1223.15c.1; -.
DR   MaxQB; Q50HP3; -.
DR   PaxDb; Q50HP3; -.
DR   EnsemblFungi; SPCC1223.15c.1; SPCC1223.15c.1:pep; SPCC1223.15c.
DR   PomBase; SPCC1223.15c; spc19.
DR   VEuPathDB; FungiDB:SPCC1223.15c; -.
DR   eggNOG; ENOG502SDEQ; Eukaryota.
DR   HOGENOM; CLU_112993_0_0_1; -.
DR   InParanoid; Q50HP3; -.
DR   OMA; DCCEEAH; -.
DR   PhylomeDB; Q50HP3; -.
DR   PRO; PR:Q50HP3; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0042729; C:DASH complex; IDA:PomBase.
DR   GO; GO:0005876; C:spindle microtubule; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:1990758; P:mitotic sister chromatid biorientation; TAS:PomBase.
DR   GO; GO:0051455; P:monopolar spindle attachment to meiosis I kinetochore; IC:PomBase.
DR   InterPro; IPR013251; DASH_Spc19.
DR   PANTHER; PTHR28262; PTHR28262; 1.
DR   Pfam; PF08287; DASH_Spc19; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW   Cytoplasm; Cytoskeleton; Kinetochore; Microtubule; Mitosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..152
FT                   /note="DASH complex subunit spc19"
FT                   /id="PRO_0000142591"
SQ   SEQUENCE   152 AA;  17494 MW;  D9C97ACBF17DFE45 CRC64;
     MSYLDGLQQC VDSLQISIGT LSSSIDTLES GIHDFPRIKH ILKVQRHFNL ISEDELSARQ
     AKFEEIVKPI LSKAFQRLED SISSLQRQED SLKTKYELQE ARLDMLKNRP ATSAFSVTTE
     SSEQLKAIIA KRQKLVYTLE RYTLQLQQKR GH