ID   SPC19_YARLI             Reviewed;         166 AA.
AC   Q6C070;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-JUN-2005, sequence version 2.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=DASH complex subunit SPC19;
DE   AltName: Full=Outer kinetochore protein SPC19;
GN   Name=SPC19; OrderedLocusNames=YALI0F27335g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the DASH complex, a microtubule-binding
CC       subcomplex of the outer kinetochore that is essential for proper
CC       chromosome segregation. The DASH complex mediates the formation and
CC       maintenance of bipolar kinetochore-microtubule attachments by forming
CC       closed rings around spindle microtubules and establishing interactions
CC       with proteins from the central kinetochore (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The DASH complex oligomerizes to form rings that encircle the
CC       microtubules. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       spindle {ECO:0000250}. Chromosome, centromere, kinetochore
CC       {ECO:0000250}. Note=Associates with the mitotic spindle and the
CC       kinetochore. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DASH complex SPC19 family. {ECO:0000305}.
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DR   EMBL; CR382132; CAG78754.2; -; Genomic_DNA.
DR   RefSeq; XP_505942.2; XM_505942.2.
DR   AlphaFoldDB; Q6C070; -.
DR   SMR; Q6C070; -.
DR   STRING; 4952.CAG78754; -.
DR   PRIDE; Q6C070; -.
DR   EnsemblFungi; CAG78754; CAG78754; YALI0_F27335g.
DR   GeneID; 2907882; -.
DR   KEGG; yli:YALI0F27335g; -.
DR   VEuPathDB; FungiDB:YALI0_F27335g; -.
DR   HOGENOM; CLU_1604034_0_0_1; -.
DR   InParanoid; Q6C070; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0042729; C:DASH complex; IBA:GO_Central.
DR   GO; GO:0005876; C:spindle microtubule; IEA:InterPro.
DR   GO; GO:0008608; P:attachment of spindle microtubules to kinetochore; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR013251; DASH_Spc19.
DR   PANTHER; PTHR28262; PTHR28262; 1.
DR   Pfam; PF08287; DASH_Spc19; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Kinetochore; Microtubule; Mitosis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..166
FT                   /note="DASH complex subunit SPC19"
FT                   /id="PRO_0000142592"
FT   COILED          119..160
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   166 AA;  19219 MW;  72A5A06059471670 CRC64;
     MTNTLDDSIG SMQNCVSIVR DTSLKLRSRA QTPEETERIK KVLQLTRKYE EVTQSEVLAA
     QQRQAAEIAP QVQDLIGGVE KQISSLHSKE RKLKSQSELN KSRLEQFPMT RREVVDVPRD
     ADNVVEVTEE ELQELEELQR EREKLKMEIS RLNLEKRKSV YGKLPQ