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SPC1L_HUMAN
ID   SPC1L_HUMAN             Reviewed;         340 AA.
AC   Q9H0A9; B4E323; Q52LS9; Q6FIH5; Q6P0L3; Q9NSE5;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 3.
DT   03-AUG-2022, entry version 157.
DE   RecName: Full=Speriolin-like protein;
DE   AltName: Full=Spermatogenesis and centriole-associated protein 1-like protein;
GN   Name=SPATC1L; Synonyms=C21orf56;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA   Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA   Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA   Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA   Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA   Klein M., Poustka A.;
RT   "Towards a catalog of human genes and proteins: sequencing and analysis of
RT   500 novel complete protein coding human cDNAs.";
RL   Genome Res. 11:422-435(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Uterus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA   Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA   Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA   Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA   Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA   Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA   Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA   Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA   Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA   Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA   Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain, Eye, Mammary gland, and Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   ASSOCIATION WITH SENSITIVITY TO ALKYLATING AGENTS.
RX   PubMed=18805990; DOI=10.1101/gad.1688508;
RA   Fry R.C., Svensson J.P., Valiathan C., Wang E., Hogan B.J.,
RA   Bhattacharya S., Bugni J.M., Whittaker C.A., Samson L.D.;
RT   "Genomic predictors of interindividual differences in response to DNA
RT   damaging agents.";
RL   Genes Dev. 22:2621-2626(2008).
CC   -!- INTERACTION:
CC       Q9H0A9; P40617: ARL4A; NbExp=3; IntAct=EBI-372911, EBI-2875746;
CC       Q9H0A9; Q9H6L4: ARMC7; NbExp=3; IntAct=EBI-372911, EBI-742909;
CC       Q9H0A9; A1L4K1: FSD2; NbExp=4; IntAct=EBI-372911, EBI-5661036;
CC       Q9H0A9; Q13422: IKZF1; NbExp=3; IntAct=EBI-372911, EBI-745305;
CC       Q9H0A9; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-372911, EBI-741037;
CC       Q9H0A9; Q8IXK0-4: PHC2; NbExp=3; IntAct=EBI-372911, EBI-10304199;
CC       Q9H0A9; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-372911, EBI-302345;
CC       Q9H0A9; Q8IUQ4: SIAH1; NbExp=3; IntAct=EBI-372911, EBI-747107;
CC       Q9H0A9; P15884: TCF4; NbExp=3; IntAct=EBI-372911, EBI-533224;
CC       Q9H0A9; P14373: TRIM27; NbExp=3; IntAct=EBI-372911, EBI-719493;
CC       Q9H0A9-2; O00154-4: ACOT7; NbExp=3; IntAct=EBI-11995806, EBI-12007918;
CC       Q9H0A9-2; Q9H6L4: ARMC7; NbExp=3; IntAct=EBI-11995806, EBI-742909;
CC       Q9H0A9-2; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-11995806, EBI-1166928;
CC       Q9H0A9-2; Q9NPB3: CABP2; NbExp=3; IntAct=EBI-11995806, EBI-12011224;
CC       Q9H0A9-2; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-11995806, EBI-11988027;
CC       Q9H0A9-2; Q96B26: EXOSC8; NbExp=3; IntAct=EBI-11995806, EBI-371922;
CC       Q9H0A9-2; O15353: FOXN1; NbExp=3; IntAct=EBI-11995806, EBI-11319000;
CC       Q9H0A9-2; A1L4K1: FSD2; NbExp=3; IntAct=EBI-11995806, EBI-5661036;
CC       Q9H0A9-2; Q9NYA3: GOLGA6A; NbExp=5; IntAct=EBI-11995806, EBI-11163335;
CC       Q9H0A9-2; Q969F1: GTF3C6; NbExp=3; IntAct=EBI-11995806, EBI-6268616;
CC       Q9H0A9-2; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-11995806, EBI-14103818;
CC       Q9H0A9-2; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-11995806, EBI-10961706;
CC       Q9H0A9-2; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-11995806, EBI-14069005;
CC       Q9H0A9-2; Q6A162: KRT40; NbExp=3; IntAct=EBI-11995806, EBI-10171697;
CC       Q9H0A9-2; Q8IVT2: MISP; NbExp=3; IntAct=EBI-11995806, EBI-2555085;
CC       Q9H0A9-2; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-11995806, EBI-11522433;
CC       Q9H0A9-2; O43639: NCK2; NbExp=5; IntAct=EBI-11995806, EBI-713635;
CC       Q9H0A9-2; P61970: NUTF2; NbExp=3; IntAct=EBI-11995806, EBI-591778;
CC       Q9H0A9-2; Q9UBU9: NXF1; NbExp=3; IntAct=EBI-11995806, EBI-398874;
CC       Q9H0A9-2; Q9UIL8: PHF11; NbExp=3; IntAct=EBI-11995806, EBI-2861403;
CC       Q9H0A9-2; O75928-2: PIAS2; NbExp=3; IntAct=EBI-11995806, EBI-348567;
CC       Q9H0A9-2; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-11995806, EBI-79165;
CC       Q9H0A9-2; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-11995806, EBI-302345;
CC       Q9H0A9-2; O15160: POLR1C; NbExp=3; IntAct=EBI-11995806, EBI-1055079;
CC       Q9H0A9-2; P62140: PPP1CB; NbExp=3; IntAct=EBI-11995806, EBI-352350;
CC       Q9H0A9-2; P47897: QARS1; NbExp=3; IntAct=EBI-11995806, EBI-347462;
CC       Q9H0A9-2; O75771: RAD51D; NbExp=3; IntAct=EBI-11995806, EBI-1055693;
CC       Q9H0A9-2; Q15415: RBMY1J; NbExp=3; IntAct=EBI-11995806, EBI-8642021;
CC       Q9H0A9-2; Q04864-2: REL; NbExp=3; IntAct=EBI-11995806, EBI-10829018;
CC       Q9H0A9-2; Q9H0A9-2: SPATC1L; NbExp=5; IntAct=EBI-11995806, EBI-11995806;
CC       Q9H0A9-2; Q8N0S2: SYCE1; NbExp=3; IntAct=EBI-11995806, EBI-6872807;
CC       Q9H0A9-2; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-11995806, EBI-750487;
CC       Q9H0A9-2; P14373: TRIM27; NbExp=3; IntAct=EBI-11995806, EBI-719493;
CC       Q9H0A9-2; Q9BU70: TRMO; NbExp=5; IntAct=EBI-11995806, EBI-2652818;
CC       Q9H0A9-2; Q969E8: TSR2; NbExp=3; IntAct=EBI-11995806, EBI-746981;
CC       Q9H0A9-2; Q9BZL1: UBL5; NbExp=3; IntAct=EBI-11995806, EBI-607755;
CC       Q9H0A9-2; Q8NAP8: ZBTB8B; NbExp=3; IntAct=EBI-11995806, EBI-17494306;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9H0A9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9H0A9-2; Sequence=VSP_039151;
CC   -!- MISCELLANEOUS: Highly variable expression among individuals is
CC       associated with differential sensitivity to the DNA alkylating agent N-
CC       methyl-N'-nitro-N-nitrosoguanidine (MNNG), decreased expression being
CC       associated with increased sensitivity.
CC   -!- SIMILARITY: Belongs to the speriolin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA95497.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AL136871; CAB66805.1; -; mRNA.
DR   EMBL; CR533451; CAG38482.1; -; mRNA.
DR   EMBL; AK304535; BAG65335.1; -; mRNA.
DR   EMBL; AP001468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP001759; BAA95497.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CH471079; EAX09307.1; -; Genomic_DNA.
DR   EMBL; BC009497; AAH09497.3; -; mRNA.
DR   EMBL; BC065570; AAH65570.2; -; mRNA.
DR   EMBL; BC084577; AAH84577.1; -; mRNA.
DR   EMBL; BC093804; AAH93804.2; -; mRNA.
DR   EMBL; BC112293; AAI12294.2; -; mRNA.
DR   CCDS; CCDS13732.1; -. [Q9H0A9-2]
DR   CCDS; CCDS46653.1; -. [Q9H0A9-1]
DR   RefSeq; NP_001136326.1; NM_001142854.1. [Q9H0A9-1]
DR   RefSeq; NP_115637.3; NM_032261.4. [Q9H0A9-2]
DR   RefSeq; XP_005261245.1; XM_005261188.4. [Q9H0A9-1]
DR   RefSeq; XP_016883969.1; XM_017028480.1. [Q9H0A9-1]
DR   AlphaFoldDB; Q9H0A9; -.
DR   SMR; Q9H0A9; -.
DR   BioGRID; 123955; 53.
DR   IntAct; Q9H0A9; 44.
DR   STRING; 9606.ENSP00000291672; -.
DR   iPTMnet; Q9H0A9; -.
DR   PhosphoSitePlus; Q9H0A9; -.
DR   BioMuta; SPATC1L; -.
DR   DMDM; 296439382; -.
DR   EPD; Q9H0A9; -.
DR   MassIVE; Q9H0A9; -.
DR   PaxDb; Q9H0A9; -.
DR   PeptideAtlas; Q9H0A9; -.
DR   PRIDE; Q9H0A9; -.
DR   ProteomicsDB; 80238; -. [Q9H0A9-1]
DR   ProteomicsDB; 80239; -. [Q9H0A9-2]
DR   Antibodypedia; 10604; 219 antibodies from 21 providers.
DR   DNASU; 84221; -.
DR   Ensembl; ENST00000291672.6; ENSP00000291672.5; ENSG00000160284.15. [Q9H0A9-1]
DR   Ensembl; ENST00000330205.10; ENSP00000333869.6; ENSG00000160284.15. [Q9H0A9-2]
DR   Ensembl; ENST00000618495.3; ENSP00000478124.1; ENSG00000274679.4. [Q9H0A9-2]
DR   Ensembl; ENST00000621926.3; ENSP00000483544.1; ENSG00000274679.4. [Q9H0A9-1]
DR   GeneID; 84221; -.
DR   KEGG; hsa:84221; -.
DR   MANE-Select; ENST00000291672.6; ENSP00000291672.5; NM_001142854.2; NP_001136326.1.
DR   UCSC; uc002zii.4; human. [Q9H0A9-1]
DR   CTD; 84221; -.
DR   DisGeNET; 84221; -.
DR   GeneCards; SPATC1L; -.
DR   HGNC; HGNC:1298; SPATC1L.
DR   HPA; ENSG00000160284; Tissue enhanced (testis).
DR   MIM; 612412; gene.
DR   neXtProt; NX_Q9H0A9; -.
DR   OpenTargets; ENSG00000160284; -.
DR   PharmGKB; PA25851; -.
DR   VEuPathDB; HostDB:ENSG00000160284; -.
DR   eggNOG; ENOG502RRP2; Eukaryota.
DR   GeneTree; ENSGT00520000055666; -.
DR   HOGENOM; CLU_107196_0_0_1; -.
DR   InParanoid; Q9H0A9; -.
DR   OMA; PAYPEAC; -.
DR   OrthoDB; 827195at2759; -.
DR   PhylomeDB; Q9H0A9; -.
DR   TreeFam; TF329273; -.
DR   PathwayCommons; Q9H0A9; -.
DR   SignaLink; Q9H0A9; -.
DR   BioGRID-ORCS; 84221; 15 hits in 1076 CRISPR screens.
DR   ChiTaRS; SPATC1L; human.
DR   GeneWiki; C21orf56; -.
DR   GenomeRNAi; 84221; -.
DR   Pharos; Q9H0A9; Tbio.
DR   PRO; PR:Q9H0A9; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   RNAct; Q9H0A9; protein.
DR   Bgee; ENSG00000160284; Expressed in right testis and 93 other tissues.
DR   Genevisible; Q9H0A9; HS.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0097224; C:sperm connecting piece; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR   GO; GO:0008154; P:actin polymerization or depolymerization; IEA:Ensembl.
DR   GO; GO:2000481; P:positive regulation of cAMP-dependent protein kinase activity; IEA:Ensembl.
DR   GO; GO:0010739; P:positive regulation of protein kinase A signaling; IEA:Ensembl.
DR   GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR   InterPro; IPR026715; SPATC1.
DR   InterPro; IPR029384; Speriolin_C.
DR   InterPro; IPR029385; Speriolin_N.
DR   PANTHER; PTHR22192; PTHR22192; 1.
DR   Pfam; PF15059; Speriolin_C; 1.
DR   Pfam; PF15058; Speriolin_N; 2.
PE   1: Evidence at protein level;
KW   Alternative splicing; Phosphoprotein; Reference proteome.
FT   CHAIN           1..340
FT                   /note="Speriolin-like protein"
FT                   /id="PRO_0000079519"
FT   REGION          42..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          94..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         60
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D9W0"
FT   MOD_RES         134
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D9W0"
FT   VAR_SEQ         1..154
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11230166,
FT                   ECO:0000303|PubMed:15489334, ECO:0000303|Ref.2"
FT                   /id="VSP_039151"
FT   VARIANT         113
FT                   /note="P -> L (in dbSNP:rs884134)"
FT                   /id="VAR_059639"
FT   VARIANT         298
FT                   /note="S -> N (in dbSNP:rs14378)"
FT                   /id="VAR_059640"
SQ   SEQUENCE   340 AA;  37613 MW;  AE8E79F7E5B50644 CRC64;
     MAEGGELMSR LLSENADLKK QVRLLKENQM LRRLLSQSCQ EGGGHDLLPP RAHAYPEAGS
     PGSGVPDFGR FTSVADTPSQ LQTSSLEDLL CSHAPLSSED DTSPGCAAPS QAPFKAFLSP
     PEPHSHRGTD RKLSPLLSPL QDSLVDKTLL EPREMVRPKK VCFSESSLPT GDRTRRSYYL
     NEIQSFAGAE KDARVVGEIA FQLDRRILAY VFPGVTRLYG FTVANIPEKI EQTSTKSLDG
     SVDERKLREL TQRYLALSAR LEKLGYSRDV HPAFSEFLIN TYGILKQRPD LRANPLHSSP
     AALRKLVIDV VPPKFLGDSL LLLNCLCELS KEDGKPLFAW
 
 
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