ID   SPC1L_MOUSE             Reviewed;         342 AA.
AC   Q9D9W0; B2RW50;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Speriolin-like protein;
DE   AltName: Full=Spermatogenesis and centriole-associated protein 1-like protein;
GN   Name=Spatc1l;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63 AND SER-136, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SIMILARITY: Belongs to the speriolin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK006410; BAB24574.1; -; mRNA.
DR   EMBL; CH466553; EDL31844.1; -; Genomic_DNA.
DR   EMBL; BC147585; AAI47586.1; -; mRNA.
DR   EMBL; BC147614; AAI47615.1; -; mRNA.
DR   CCDS; CCDS23949.1; -.
DR   RefSeq; NP_083937.1; NM_029661.1.
DR   AlphaFoldDB; Q9D9W0; -.
DR   SMR; Q9D9W0; -.
DR   STRING; 10090.ENSMUSP00000009259; -.
DR   iPTMnet; Q9D9W0; -.
DR   PhosphoSitePlus; Q9D9W0; -.
DR   PaxDb; Q9D9W0; -.
DR   PRIDE; Q9D9W0; -.
DR   ProteomicsDB; 263315; -.
DR   Antibodypedia; 10604; 219 antibodies from 21 providers.
DR   Ensembl; ENSMUST00000009259; ENSMUSP00000009259; ENSMUSG00000009115.
DR   GeneID; 76573; -.
DR   KEGG; mmu:76573; -.
DR   UCSC; uc007fur.1; mouse.
DR   CTD; 84221; -.
DR   MGI; MGI:1923823; Spatc1l.
DR   VEuPathDB; HostDB:ENSMUSG00000009115; -.
DR   eggNOG; ENOG502RRP2; Eukaryota.
DR   GeneTree; ENSGT00520000055666; -.
DR   HOGENOM; CLU_045264_0_0_1; -.
DR   InParanoid; Q9D9W0; -.
DR   OMA; PAYPEAC; -.
DR   OrthoDB; 827195at2759; -.
DR   PhylomeDB; Q9D9W0; -.
DR   TreeFam; TF329273; -.
DR   BioGRID-ORCS; 76573; 3 hits in 72 CRISPR screens.
DR   PRO; PR:Q9D9W0; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; Q9D9W0; protein.
DR   Bgee; ENSMUSG00000009115; Expressed in seminiferous tubule of testis and 30 other tissues.
DR   ExpressionAtlas; Q9D9W0; baseline and differential.
DR   Genevisible; Q9D9W0; MM.
DR   GO; GO:0005813; C:centrosome; IDA:MGI.
DR   GO; GO:0097224; C:sperm connecting piece; IDA:MGI.
DR   GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IPI:MGI.
DR   GO; GO:0008154; P:actin polymerization or depolymerization; IMP:MGI.
DR   GO; GO:2000481; P:positive regulation of cAMP-dependent protein kinase activity; IDA:MGI.
DR   GO; GO:0010739; P:positive regulation of protein kinase A signaling; IPI:MGI.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; IDA:MGI.
DR   GO; GO:0007283; P:spermatogenesis; IMP:MGI.
DR   InterPro; IPR026715; SPATC1.
DR   InterPro; IPR029384; Speriolin_C.
DR   InterPro; IPR029385; Speriolin_N.
DR   PANTHER; PTHR22192; PTHR22192; 1.
DR   Pfam; PF15059; Speriolin_C; 1.
DR   Pfam; PF15058; Speriolin_N; 2.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..342
FT                   /note="Speriolin-like protein"
FT                   /id="PRO_0000079520"
FT   MOD_RES         63
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         136
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
SQ   SEQUENCE   342 AA;  38164 MW;  339806D60F5CC2FA CRC64;
     MAEGSELMSR LMSENADLKK QVRLLKENQM LKRLLSESCQ ESCGRGSRDL LYPKVPTYPE
     ACSPGNGGPD FGRFAGVPDT PSQLPTSSLE DLLCSHAPLS SEDEASPGCA TTSQMPFKSF
     LSPSELHSRI ADRKLSPLLS PLQDSLADKT LLEPREISRP KKVCFSESNL PTGDRSRRTY
     YLNEIQSFSG AEKDGRIVGE IAFQLDRRIL AYVFPGVTRL YGFTVSNIPE KIKQTSIKSL
     DGSVDEKKLR ELTHRYLTLT ARLEKLGYSR EVHPVFSEFL INTYGILKQR PDLRANPLHS
     SPAALRKLVI DIVPPKFLGD SLLLLNCLCE LSKEDSKPLF AW