SPC24_ASHGO
ID SPC24_ASHGO Reviewed; 204 AA.
AC Q753W9;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Probable kinetochore protein SPC24;
GN Name=SPC24; OrderedLocusNames=AFR203C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000250}.
CC -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC SPC24 and SPC25. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q04477}.
CC Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q04477}.
CC Note=Associated with kinetochores. {ECO:0000250|UniProtKB:Q04477}.
CC -!- SIMILARITY: Belongs to the SPC24 family. {ECO:0000305}.
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DR EMBL; AE016819; AAS53574.1; -; Genomic_DNA.
DR RefSeq; NP_985750.1; NM_211104.1.
DR AlphaFoldDB; Q753W9; -.
DR SMR; Q753W9; -.
DR STRING; 33169.AAS53574; -.
DR EnsemblFungi; AAS53574; AAS53574; AGOS_AFR203C.
DR GeneID; 4622011; -.
DR KEGG; ago:AGOS_AFR203C; -.
DR eggNOG; ENOG502S3GS; Eukaryota.
DR HOGENOM; CLU_095757_0_0_1; -.
DR InParanoid; Q753W9; -.
DR OMA; FKTKYIW; -.
DR Proteomes; UP000000591; Chromosome VI.
DR GO; GO:0031262; C:Ndc80 complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0098653; P:centromere clustering; IEA:EnsemblFungi.
DR GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR Gene3D; 3.30.160.430; -; 1.
DR InterPro; IPR013252; Ndc80_Spc24.
DR InterPro; IPR038066; Spc24_Fungi_globular_sf.
DR PANTHER; PTHR22142; PTHR22142; 1.
DR Pfam; PF08286; Spc24; 1.
DR SUPFAM; SSF143026; SSF143026; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW Kinetochore; Mitosis; Nucleus; Reference proteome.
FT CHAIN 1..204
FT /note="Probable kinetochore protein SPC24"
FT /id="PRO_0000246657"
FT COILED 29..127
FT /evidence="ECO:0000255"
SQ SEQUENCE 204 AA; 22966 MW; FE787BB5D8B117A8 CRC64;
MPSQAPGPDV LENPADLLRQ TRENFSIAHD LQLLNATEEN LRRLMQRTQQ LEAKGAQELS
ELQAQQTERA QAAEAMRAEK ETQAQHLQAL THSQDLVRLA NELEELEQQL VSLRAELDEG
MTQLLQTSEP TAAFQGDAEH EQQSPEVQTN LLKLQLYSSL GVTLDTEHNQ ALIERGDAAG
IDLIALEDDS LSPFFRTKYV WDRL
