ID   SPC24_ASPFU             Reviewed;         200 AA.
AC   Q4X0I7;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 2.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Probable kinetochore protein spc24;
GN   Name=spc24; ORFNames=AFUA_2G13330;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of at least
CC       ndc80, nuf2 and spc24. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UST6}.
CC       Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q9UST6}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole
CC       body {ECO:0000250|UniProtKB:Q9UST6}. Note=Associated with kinetochores.
CC       {ECO:0000250|UniProtKB:Q9UST6}.
CC   -!- SIMILARITY: Belongs to the SPC24 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL93628.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AAHF01000001; EAL93628.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_755666.1; XM_750573.1.
DR   AlphaFoldDB; Q4X0I7; -.
DR   SMR; Q4X0I7; -.
DR   STRING; 746128.CADAFUBP00002837; -.
DR   GeneID; 3513168; -.
DR   KEGG; afm:AFUA_2G13330; -.
DR   VEuPathDB; FungiDB:Afu2g13330; -.
DR   eggNOG; ENOG502S52R; Eukaryota.
DR   HOGENOM; CLU_091441_1_1_1; -.
DR   InParanoid; Q4X0I7; -.
DR   OrthoDB; 1614435at2759; -.
DR   Proteomes; UP000002530; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0031262; C:Ndc80 complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR   Gene3D; 3.30.160.430; -; 1.
DR   InterPro; IPR013252; Ndc80_Spc24.
DR   InterPro; IPR038066; Spc24_Fungi_globular_sf.
DR   PANTHER; PTHR22142; PTHR22142; 1.
DR   Pfam; PF08286; Spc24; 1.
DR   SUPFAM; SSF143026; SSF143026; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil; Cytoplasm;
KW   Cytoskeleton; Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..200
FT                   /note="Probable kinetochore protein spc24"
FT                   /id="PRO_0000246658"
FT   COILED          39..129
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   200 AA;  22783 MW;  1A83BFE1FFA0958D CRC64;
     MLLDEDPATL IHHTIGNFNI QPDKQAVTRI NDSLSTLQQS RELRMRDAES ALRKLSRNLH
     ALTAQHEEAV SSHDSAKHAA QMVELDTKKF RIAKAATELE IESERLEGEL EMLKERLAEL
     EAQGLEGDEA TRREREADDA TILRLKIYRS LGIDIEADEA GNFSKAVIRN SRKGDVHVVN
     MDPKFSRFFY ANYFWSTMQG