SPC24_ASPOR
ID SPC24_ASPOR Reviewed; 200 AA.
AC Q2UF95;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Probable kinetochore protein spc24;
GN Name=spc24; ORFNames=AO090026000295;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000250}.
CC -!- SUBUNIT: Component of the NDC80 complex, which consists of ndc80, nuf2,
CC spc24 and spc25. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UST6}.
CC Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q9UST6}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole
CC body {ECO:0000250|UniProtKB:Q9UST6}. Note=Associated with kinetochores.
CC {ECO:0000250|UniProtKB:Q9UST6}.
CC -!- SIMILARITY: Belongs to the SPC24 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP007159; BAE59770.1; -; Genomic_DNA.
DR RefSeq; XP_001821772.1; XM_001821720.2.
DR AlphaFoldDB; Q2UF95; -.
DR SMR; Q2UF95; -.
DR STRING; 510516.Q2UF95; -.
DR EnsemblFungi; BAE59770; BAE59770; AO090026000295.
DR GeneID; 5993800; -.
DR KEGG; aor:AO090026000295; -.
DR VEuPathDB; FungiDB:AO090026000295; -.
DR HOGENOM; CLU_091441_1_0_1; -.
DR OMA; TEKFRIA; -.
DR Proteomes; UP000006564; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.430; -; 1.
DR InterPro; IPR013252; Ndc80_Spc24.
DR InterPro; IPR038066; Spc24_Fungi_globular_sf.
DR PANTHER; PTHR22142; PTHR22142; 1.
DR Pfam; PF08286; Spc24; 1.
DR SUPFAM; SSF143026; SSF143026; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Centromere; Chromosome; Coiled coil; Cytoplasm;
KW Cytoskeleton; Kinetochore; Mitosis; Nucleus; Reference proteome.
FT CHAIN 1..200
FT /note="Probable kinetochore protein spc24"
FT /id="PRO_0000246659"
FT COILED 42..129
FT /evidence="ECO:0000255"
SQ SEQUENCE 200 AA; 22876 MW; 32C7FA02BF07F2F2 CRC64;
MLLDENPGTL IHHTIGNFNI QPDKQAVTRI NDSLSTLQQS RELRMREAES SLRKLSRHLH
SLNAQHEEAV AAHDSSKHAA DMVELDTKKF RIAKAATELE IESERLESEL EMLKERLADL
EAQGLEGDEA TRRERELDDA TILRLKIYRS LGVDIEADDA GNFNKAVIRN SRKGDVHVVN
IDPKFSRFFY SNYFWSTMQG
