ID   SPC24_CANAL             Reviewed;         252 AA.
AC   Q5ALU2; A0A1D8PGE5;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 2.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Probable kinetochore protein SPC24;
GN   Name=SPC24; OrderedLocusNames=CAALFM_C201730WA;
GN   ORFNames=CaO19.1484, CaO19.9059;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC       SPC24 and SPC25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPC24 family. {ECO:0000305}.
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DR   EMBL; CP017624; AOW27219.1; -; Genomic_DNA.
DR   RefSeq; XP_722533.2; XM_717440.2.
DR   AlphaFoldDB; Q5ALU2; -.
DR   SMR; Q5ALU2; -.
DR   PRIDE; Q5ALU2; -.
DR   GeneID; 3635732; -.
DR   KEGG; cal:CAALFM_C201730WA; -.
DR   CGD; CAL0000192334; orf19.9059.
DR   VEuPathDB; FungiDB:C2_01730W_A; -.
DR   eggNOG; ENOG502S52R; Eukaryota.
DR   HOGENOM; CLU_091441_0_0_1; -.
DR   InParanoid; Q5ALU2; -.
DR   OrthoDB; 1614435at2759; -.
DR   PRO; PR:Q5ALU2; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0031262; C:Ndc80 complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR   Gene3D; 3.30.160.430; -; 1.
DR   InterPro; IPR013252; Ndc80_Spc24.
DR   InterPro; IPR038066; Spc24_Fungi_globular_sf.
DR   PANTHER; PTHR22142; PTHR22142; 1.
DR   Pfam; PF08286; Spc24; 1.
DR   SUPFAM; SSF143026; SSF143026; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..252
FT                   /note="Probable kinetochore protein SPC24"
FT                   /id="PRO_0000246660"
FT   REGION          194..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          41..71
FT                   /evidence="ECO:0000255"
FT   COILED          115..170
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        199..217
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   252 AA;  29160 MW;  BF90D35780BC4151 CRC64;
     MTTSVDKLNK LIEEVNNQDE LQLIEEINLY IKTLYELRQV KIDQLSNIIH QLNQQIITSN
     KEINQLNKIN DYNYELINVN NFNFVSQQSF QFTNFDRSSS SSSESTNNIF QMINKRLNEL
     DNLKVVIVKE LTDLETNLNN LKYKQNNLHE SMEDINDKLD KLLNDMDKSG IMEQDPSILR
     INLFRNLGIK LENMPPNANS GGGGDSNSNS SNNNNTEEDC VIITDDNNNV NILNIEPKLS
     DYFISNYIWD KL