ID   SPC24_CANGA             Reviewed;         201 AA.
AC   Q6FN12;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Probable kinetochore protein SPC24;
GN   Name=SPC24; OrderedLocusNames=CAGL0K03619g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC       SPC24 and SPC25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q04477}.
CC       Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q04477}.
CC       Note=Associated with kinetochores. {ECO:0000250|UniProtKB:Q04477}.
CC   -!- SIMILARITY: Belongs to the SPC24 family. {ECO:0000305}.
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DR   EMBL; CR380957; CAG61343.1; -; Genomic_DNA.
DR   RefSeq; XP_448382.1; XM_448382.1.
DR   AlphaFoldDB; Q6FN12; -.
DR   SMR; Q6FN12; -.
DR   STRING; 5478.XP_448382.1; -.
DR   EnsemblFungi; CAG61343; CAG61343; CAGL0K03619g.
DR   GeneID; 2890132; -.
DR   KEGG; cgr:CAGL0K03619g; -.
DR   CGD; CAL0134409; CAGL0K03619g.
DR   VEuPathDB; FungiDB:CAGL0K03619g; -.
DR   eggNOG; ENOG502S3GS; Eukaryota.
DR   HOGENOM; CLU_095757_0_0_1; -.
DR   InParanoid; Q6FN12; -.
DR   OMA; FKTKYIW; -.
DR   Proteomes; UP000002428; Chromosome K.
DR   GO; GO:0031262; C:Ndc80 complex; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0098653; P:centromere clustering; IEA:EnsemblFungi.
DR   GO; GO:0007059; P:chromosome segregation; IEA:EnsemblFungi.
DR   Gene3D; 3.30.160.430; -; 1.
DR   InterPro; IPR013252; Ndc80_Spc24.
DR   InterPro; IPR038066; Spc24_Fungi_globular_sf.
DR   PANTHER; PTHR22142; PTHR22142; 1.
DR   Pfam; PF08286; Spc24; 1.
DR   SUPFAM; SSF143026; SSF143026; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..201
FT                   /note="Probable kinetochore protein SPC24"
FT                   /id="PRO_0000246661"
FT   COILED          24..129
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   201 AA;  23155 MW;  48A281542F00FDAA CRC64;
     MASTEEIVQM MQEASAEFAE ADDVSFLDKM NSNIAQLEQQ LREQMDESRQ NIAKLEINLI
     DTEKSIGSLR ELMKDATDEA TIMKGSDKLN NLIDELQATE NEIQMMNSEI EKKVSKLVED
     EDNTSSEYEM ISKELEQEYD PVFASNILKL KLYRSLGVRL DLDNNQILIQ NKELGTIDTL
     PLEDELTEFF KVKYIWSRIG K