ID   SPC24_DEBHA             Reviewed;         227 AA.
AC   Q6BXB6;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Probable kinetochore protein SPC24;
GN   Name=SPC24; OrderedLocusNames=DEHA2B04400g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC       SPC24 and SPC25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPC24 family. {ECO:0000305}.
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DR   EMBL; CR382134; CAG85147.1; -; Genomic_DNA.
DR   RefSeq; XP_457153.1; XM_457153.1.
DR   AlphaFoldDB; Q6BXB6; -.
DR   SMR; Q6BXB6; -.
DR   STRING; 4959.XP_457153.1; -.
DR   EnsemblFungi; CAG85147; CAG85147; DEHA2B04400g.
DR   GeneID; 2913209; -.
DR   KEGG; dha:DEHA2B04400g; -.
DR   VEuPathDB; FungiDB:DEHA2B04400g; -.
DR   eggNOG; ENOG502S52R; Eukaryota.
DR   HOGENOM; CLU_091441_0_0_1; -.
DR   InParanoid; Q6BXB6; -.
DR   OMA; FKTKYIW; -.
DR   OrthoDB; 1614435at2759; -.
DR   Proteomes; UP000000599; Chromosome B.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.160.430; -; 1.
DR   InterPro; IPR013252; Ndc80_Spc24.
DR   InterPro; IPR038066; Spc24_Fungi_globular_sf.
DR   PANTHER; PTHR22142; PTHR22142; 1.
DR   Pfam; PF08286; Spc24; 1.
DR   SUPFAM; SSF143026; SSF143026; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..227
FT                   /note="Probable kinetochore protein SPC24"
FT                   /id="PRO_0000246662"
FT   COILED          41..70
FT                   /evidence="ECO:0000255"
FT   COILED          107..155
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   227 AA;  26412 MW;  84948CA0DFE55889 CRC64;
     MFHEKPDKLL LSSIESFEIE PDLLTLRRIE EVINKTNQYR SNTIENYETK LNTMKSEFQS
     LMSEINLLTK VSGINYENLK LLGNGNEESM GDLSNKNIFN VMNEKSIELD NLKLSLAKNL
     NDLESQINSM NITKKDLMEK YELVKMKNDN LINDNILKNP DSKAIKINIY KNLGVEIESG
     EEGETENKQD KVIIYNKETN LSSILNIDDK YSEYFITNYI WDRLQGY