ID   SPC24_KLULA             Reviewed;         189 AA.
AC   Q6CNJ1;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Probable kinetochore protein SPC24;
GN   Name=SPC24; OrderedLocusNames=KLLA0E12199g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC       SPC24 and SPC25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPC24 family. {ECO:0000305}.
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DR   EMBL; CR382125; CAG99585.1; -; Genomic_DNA.
DR   RefSeq; XP_454498.1; XM_454498.1.
DR   AlphaFoldDB; Q6CNJ1; -.
DR   SMR; Q6CNJ1; -.
DR   EnsemblFungi; CAG99585; CAG99585; KLLA0_E12189g.
DR   GeneID; 2894210; -.
DR   KEGG; kla:KLLA0_E12189g; -.
DR   HOGENOM; CLU_1434641_0_0_1; -.
DR   InParanoid; Q6CNJ1; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..189
FT                   /note="Probable kinetochore protein SPC24"
FT                   /id="PRO_0000246665"
FT   COILED          24..124
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   189 AA;  22048 MW;  18E856D4D0F3F010 CRC64;
     MSRLNDPVEL LQQTRSNFII ESDVSNIKEI KSNMRQLTKL MAEKQTHHNE LMKQLQSQLQ
     RQQTKVQALK KNFQEQTSQV KRVEDELNIP KLQQDIDKLV QEINQLRDTI QEGIQKVVET
     QKQLLNDDTD AAHTIDEEPI GKDDKIRVLK LKLFHSLDVA LYNDQLLDLR NEARPLSSSS
     SSHNIWDEL