ID   SPC24_NEUCR             Reviewed;         221 AA.
AC   Q7S8M2;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Probable kinetochore protein spc24;
DE   AltName: Full=Kinetochore protein 3;
GN   Name=kpr-3; Synonyms=spc24; ORFNames=NCU05312;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of kpr-1/ndc80,
CC       kpr-2/nuf2, kpr-3/spc24 and kpr-4/spc25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UST6}.
CC       Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q9UST6}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole
CC       body {ECO:0000250|UniProtKB:Q9UST6}. Note=Associated with kinetochores.
CC       {ECO:0000250|UniProtKB:Q9UST6}.
CC   -!- SIMILARITY: Belongs to the SPC24 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA32689.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CM002239; EAA32689.2; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_961925.2; XM_956832.3.
DR   AlphaFoldDB; Q7S8M2; -.
DR   SMR; Q7S8M2; -.
DR   STRING; 5141.EFNCRP00000005032; -.
DR   EnsemblFungi; EAA32689; EAA32689; NCU05312.
DR   GeneID; 3878077; -.
DR   KEGG; ncr:NCU05312; -.
DR   HOGENOM; CLU_091441_1_0_1; -.
DR   InParanoid; Q7S8M2; -.
DR   Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0031262; C:Ndc80 complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR   Gene3D; 3.30.160.430; -; 1.
DR   InterPro; IPR013252; Ndc80_Spc24.
DR   InterPro; IPR038066; Spc24_Fungi_globular_sf.
DR   PANTHER; PTHR22142; PTHR22142; 1.
DR   Pfam; PF08286; Spc24; 1.
DR   SUPFAM; SSF143026; SSF143026; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil; Cytoplasm;
KW   Cytoskeleton; Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..221
FT                   /note="Probable kinetochore protein spc24"
FT                   /id="PRO_0000246666"
FT   REGION          126..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          42..127
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        135..152
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   221 AA;  24728 MW;  790DFD3D2FE92564 CRC64;
     MLLEEDPSTL IAHTTQNFNI TPDRHAVSRV AESLSTLQQA RDLRLRESET NLKKLARTLN
     TLQSQHQEVT SSHSSAEHAS LISRLDTQKF RVAKNVSDLE METERLQTQL AELQARLQEL
     ELQGVDGGDA SAAGGATSTG ENNGNGSAGN GGQVRSVEDE VLLRLKVYRS LGIEIEREEQ
     DGGEFTRAVV RNDRRGDVCV VNVDRHRFSR FFYANYFWQT L