ID   SPC24_XENTR             Reviewed;         199 AA.
AC   Q6P8A1;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Kinetochore protein spc24;
GN   Name=spc24; Synonyms=spbc24; ORFNames=TEgg077l22.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. Required for kinetochore integrity and the
CC       organization of stable microtubule binding sites in the outer plate of
CC       the kinetochore. The NDC80 complex synergistically enhances the
CC       affinity of the SKA1 complex for microtubules and may allow the NDC80
CC       complex to track depolymerizing microtubules.
CC       {ECO:0000250|UniProtKB:Q8NBT2}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which is composed of ndc80,
CC       cdca1, spbc24 and spbc25. The NDC80 complex interacts with mis12 and
CC       zwint (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8NBT2}.
CC       Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q8NBT2}.
CC       Note=Localizes to kinetochores from late prophase to anaphase.
CC       Localizes specifically to the outer plate of the kinetochore.
CC       {ECO:0000250|UniProtKB:Q8NBT2}.
CC   -!- SIMILARITY: Belongs to the SPC24 family. {ECO:0000305}.
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DR   EMBL; CR761127; CAJ81671.1; -; mRNA.
DR   EMBL; BC061328; AAH61328.1; -; mRNA.
DR   RefSeq; NP_989057.1; NM_203726.1.
DR   AlphaFoldDB; Q6P8A1; -.
DR   SMR; Q6P8A1; -.
DR   STRING; 8364.ENSXETP00000057635; -.
DR   PaxDb; Q6P8A1; -.
DR   DNASU; 394654; -.
DR   GeneID; 394654; -.
DR   KEGG; xtr:394654; -.
DR   CTD; 147841; -.
DR   Xenbase; XB-GENE-974559; spc24.
DR   eggNOG; ENOG502S26V; Eukaryota.
DR   InParanoid; Q6P8A1; -.
DR   OrthoDB; 1602618at2759; -.
DR   Reactome; R-XTR-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-XTR-2467813; Separation of Sister Chromatids.
DR   Reactome; R-XTR-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-XTR-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-XTR-9648025; EML4 and NUDC in mitotic spindle formation.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0031262; C:Ndc80 complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR   InterPro; IPR013252; Ndc80_Spc24.
DR   PANTHER; PTHR22142; PTHR22142; 1.
DR   Pfam; PF08286; Spc24; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..199
FT                   /note="Kinetochore protein spc24"
FT                   /id="PRO_0000249563"
FT   COILED          46..134
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   199 AA;  22870 MW;  ED02F567EE10EE9C CRC64;
     MLCEQIKEYV DVSREIVKVM VSDSAAVALK KSLDRQEAMI DLLLDTETEA SQLIRDFMAV
     EEKVAQTLLD TEETKQKTSS KLQKIERELQ EKIEKNSSLE SGIKFLQKEL EELKMMEEEI
     ADMEREADED TTTVIPSAVY LAKLFHNVTK IDWDYNCDPS LIKGIHYGGE IAQPISIDSN
     QHSKIFICNY LWSLLSTDW