ID   SPC24_YARLI             Reviewed;         189 AA.
AC   Q6C7C3;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Probable kinetochore protein SPC24;
GN   Name=SPC24; OrderedLocusNames=YALI0E01980g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC       SPC24 and SPC25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q04477}.
CC       Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q04477}.
CC       Note=Associated with kinetochores. {ECO:0000250|UniProtKB:Q04477}.
CC   -!- SIMILARITY: Belongs to the SPC24 family. {ECO:0000305}.
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DR   EMBL; CR382131; CAG79018.1; -; Genomic_DNA.
DR   RefSeq; XP_503439.1; XM_503439.1.
DR   AlphaFoldDB; Q6C7C3; -.
DR   SMR; Q6C7C3; -.
DR   STRING; 4952.CAG79018; -.
DR   EnsemblFungi; CAG79018; CAG79018; YALI0_E01980g.
DR   GeneID; 2912075; -.
DR   KEGG; yli:YALI0E01980g; -.
DR   VEuPathDB; FungiDB:YALI0_E01980g; -.
DR   HOGENOM; CLU_091441_0_0_1; -.
DR   InParanoid; Q6C7C3; -.
DR   OMA; QFIEDEN; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0031262; C:Ndc80 complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR   Gene3D; 3.30.160.430; -; 1.
DR   InterPro; IPR013252; Ndc80_Spc24.
DR   InterPro; IPR038066; Spc24_Fungi_globular_sf.
DR   PANTHER; PTHR22142; PTHR22142; 1.
DR   Pfam; PF08286; Spc24; 1.
DR   SUPFAM; SSF143026; SSF143026; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..189
FT                   /note="Probable kinetochore protein SPC24"
FT                   /id="PRO_0000246668"
FT   COILED          36..119
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   189 AA;  21475 MW;  083805B92C28FF61 CRC64;
     MDPIDLLRDV AKSFSTNEEI ASTERVSVDI TRLSLFREAK LAEARDKLQD QIRQRDLCQE
     SVAGDSTTSE RTQHVHELER EKMRLARAIN DLEETLNATQ AATSKLNAEL ELVEKESQQP
     IESAVENDSS AALQLKLFRT LGVTFDAEKP EKYTKCMIRS NTTSNVATLD LNVKEYSGFF
     ITNYIWDKL