SPC25_ASPOR
ID SPC25_ASPOR Reviewed; 264 AA.
AC Q2UPH5;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Probable kinetochore protein spc25;
GN Name=spc25; ORFNames=AO090005001640;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000250}.
CC -!- SUBUNIT: Component of the NDC80 complex, which consists of ndc80, nuf2,
CC spc24 and spc25. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P40014}.
CC Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:P40014}.
CC Note=Associated with kinetochores. {ECO:0000250|UniProtKB:P40014}.
CC -!- SIMILARITY: Belongs to the SPC25 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP007151; BAE56540.1; -; Genomic_DNA.
DR RefSeq; XP_001818542.1; XM_001818490.1.
DR AlphaFoldDB; Q2UPH5; -.
DR SMR; Q2UPH5; -.
DR STRING; 510516.Q2UPH5; -.
DR EnsemblFungi; BAE56540; BAE56540; AO090005001640.
DR GeneID; 5990487; -.
DR KEGG; aor:AO090005001640; -.
DR VEuPathDB; FungiDB:AO090005001640; -.
DR HOGENOM; CLU_065188_0_0_1; -.
DR OMA; HEDQRMK; -.
DR Proteomes; UP000006564; Chromosome 1.
DR GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:InterPro.
DR InterPro; IPR045143; Spc25.
DR InterPro; IPR013255; Spc25_C.
DR PANTHER; PTHR14281; PTHR14281; 1.
DR Pfam; PF08234; Spindle_Spc25; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW Kinetochore; Mitosis; Nucleus; Reference proteome.
FT CHAIN 1..264
FT /note="Probable kinetochore protein spc25"
FT /id="PRO_0000246670"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 59..152
FT /evidence="ECO:0000255"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 264 AA; 30709 MW; D1067390672A7213 CRC64;
MASSFEPSLS TSGMRPPLTS ADAPSMADSL PSINFGFEDL RNRMAQFTAR FDAFIEKGRK
QILEERNQFK IGLAELQEDQ RMKQRDIEIL NLKSQTHDQT IQKEAAEAAE MHGTIASVTM
ERDSRLAKRD RLKQQINETQ KAINQKLEAQ KAHARHLDAQ ARLNIPELEF WQDYLCLRIE
GAGREDRLKF IFSHLLEKDW EAEAWFELGT SSRDYDVFHT RPKVDRDALN GELDILNEDR
DFGAFLKRMR RLLVEKMQQK RPTI
