ID   SPC25_CANAL             Reviewed;         239 AA.
AC   Q59PT6; A0A1D8PT32;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Probable kinetochore protein SPC25;
GN   Name=SPC25; OrderedLocusNames=CAALFM_CR05840WA;
GN   ORFNames=CaO19.13949, CaO19.6628;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC       SPC24 and SPC25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P40014}.
CC       Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:P40014}.
CC       Note=Associated with kinetochores. {ECO:0000250|UniProtKB:P40014}.
CC   -!- SIMILARITY: Belongs to the SPC25 family. {ECO:0000305}.
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DR   EMBL; CP017630; AOW31298.1; -; Genomic_DNA.
DR   RefSeq; XP_711694.1; XM_706602.1.
DR   AlphaFoldDB; Q59PT6; -.
DR   SMR; Q59PT6; -.
DR   STRING; 237561.Q59PT6; -.
DR   GeneID; 3646704; -.
DR   KEGG; cal:CAALFM_CR05840WA; -.
DR   CGD; CAL0000186415; orf19.13949.
DR   VEuPathDB; FungiDB:CR_05840W_A; -.
DR   eggNOG; KOG4657; Eukaryota.
DR   HOGENOM; CLU_085127_0_0_1; -.
DR   InParanoid; Q59PT6; -.
DR   OMA; HEDQRMK; -.
DR   OrthoDB; 1460234at2759; -.
DR   PRO; PR:Q59PT6; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:InterPro.
DR   InterPro; IPR045143; Spc25.
DR   InterPro; IPR013255; Spc25_C.
DR   PANTHER; PTHR14281; PTHR14281; 1.
DR   Pfam; PF08234; Spindle_Spc25; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..239
FT                   /note="Probable kinetochore protein SPC25"
FT                   /id="PRO_0000246671"
FT   COILED          19..139
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   239 AA;  27936 MW;  6B474B12E5175610 CRC64;
     MDTAERAYEK FQNQMIAFDN LKIEMNELAV DLDQQLSDKQ SLILQQEQDH KQKVNDLTNQ
     EYKLKLQAKS LKEKENATRD KLNLAMRSLE QQKSKVEDLV KKKQSLVDTK QDLESQIKQL
     ETAIDQGTRE LNKSNDNMSL QMNKNLVELN KYEIYTGLKI EVQSNELMCF KFFNLDPNDY
     DREFAITLNI GGSTYSIENT SPKLSDETVE QIQGKLNQGR QLSKFLKEVR TLFKDFVQY