ID   SPC25_CRYNJ             Reviewed;         272 AA.
AC   P0CR66; Q55S37; Q5KGI8;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Probable kinetochore protein SPC25;
GN   Name=SPC25; OrderedLocusNames=CNE03460;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of at least
CC       NDC80, NUF2 and SPC25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P40014}.
CC       Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:P40014}.
CC       Note=Associated with kinetochores. {ECO:0000250|UniProtKB:P40014}.
CC   -!- SIMILARITY: Belongs to the SPC25 family. {ECO:0000305}.
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DR   EMBL; AE017345; AAW43605.1; -; Genomic_DNA.
DR   RefSeq; XP_570912.1; XM_570912.1.
DR   AlphaFoldDB; P0CR66; -.
DR   SMR; P0CR66; -.
DR   STRING; 5207.AAW43605; -.
DR   PaxDb; P0CR66; -.
DR   EnsemblFungi; AAW43605; AAW43605; CNE03460.
DR   VEuPathDB; FungiDB:CNE03460; -.
DR   eggNOG; KOG4657; Eukaryota.
DR   HOGENOM; CLU_093947_0_0_1; -.
DR   InParanoid; P0CR66; -.
DR   OMA; HEDQRMK; -.
DR   OrthoDB; 1460234at2759; -.
DR   Proteomes; UP000002149; Chromosome 5.
DR   GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:InterPro.
DR   InterPro; IPR045143; Spc25.
DR   InterPro; IPR013255; Spc25_C.
DR   PANTHER; PTHR14281; PTHR14281; 1.
DR   Pfam; PF08234; Spindle_Spc25; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..272
FT                   /note="Probable kinetochore protein SPC25"
FT                   /id="PRO_0000246673"
FT   COILED          62..174
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   272 AA;  30873 MW;  94FB54CBAA4F1722 CRC64;
     MAPTTYAVPP RPASLHFLLE SSTSKNGVPS LDLRWEPFQR HIESFLNAID AYTQAARTEI
     VARATDHTAA VRDLKADKEE MERGIQLQRE SEGEMLATLE AERHVVADLN ASLSHLQSSL
     TKIKEKSSAL DAELQSERKE VKAMQAEKER QTNVLNNMRE RDTTELKQLE EALGWRVEGI
     KQDQLLMRFT LIDPEDPARE FSIIVDVSKQ VYSVPNCDPP IPSLPDLVRQ LNFDRDLFAF
     IKRVRIAFRA LIPNPPNPST KFDDLTGPSR SR