ID   SPC25_DEBHA             Reviewed;         231 AA.
AC   Q6BNN6;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Probable kinetochore protein SPC25;
GN   Name=SPC25; OrderedLocusNames=DEHA2E20262g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC       SPC24 and SPC25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P40014}.
CC       Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:P40014}.
CC       Note=Associated with kinetochores. {ECO:0000250|UniProtKB:P40014}.
CC   -!- SIMILARITY: Belongs to the SPC25 family. {ECO:0000305}.
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DR   EMBL; CR382137; CAG88457.2; -; Genomic_DNA.
DR   RefSeq; XP_460184.2; XM_460184.2.
DR   AlphaFoldDB; Q6BNN6; -.
DR   SMR; Q6BNN6; -.
DR   STRING; 4959.XP_460184.2; -.
DR   EnsemblFungi; CAG88457; CAG88457; DEHA2E20262g.
DR   GeneID; 2902758; -.
DR   KEGG; dha:DEHA2E20262g; -.
DR   VEuPathDB; FungiDB:DEHA2E20262g; -.
DR   eggNOG; KOG4657; Eukaryota.
DR   HOGENOM; CLU_085127_0_0_1; -.
DR   InParanoid; Q6BNN6; -.
DR   OMA; HEDQRMK; -.
DR   OrthoDB; 1460234at2759; -.
DR   Proteomes; UP000000599; Chromosome E.
DR   GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:InterPro.
DR   InterPro; IPR045143; Spc25.
DR   InterPro; IPR013255; Spc25_C.
DR   PANTHER; PTHR14281; PTHR14281; 1.
DR   Pfam; PF08234; Spindle_Spc25; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..231
FT                   /note="Probable kinetochore protein SPC25"
FT                   /id="PRO_0000246674"
FT   COILED          45..130
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   231 AA;  26658 MW;  BEA330D949B77CB1 CRC64;
     MSTANKSPID EFESLQSLMN DFSAKFDTAL TQKRSAIIND KQLHYVKVNE LKNQETQLQS
     DIEGLKQKEI KVKDTIKRTM EDLQMQQLKV DELARKQDSL LDEKDELQTE IDNLSSQVQT
     TTDSLEKSSN NLAEQLRKDY PELLKYEQHL GLKIEVIGQD SLKFVFSNID PNDLDKEVWC
     ELLVGGELFK VGDSFPPLAP DIITLLENEF NHHREFVKFL KTVRALLMDL I