ID   SPC25_DROGR             Reviewed;         209 AA.
AC   B4JEY0;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Kinetochore protein Spc25 {ECO:0000250|UniProtKB:Q9V3V7};
GN   Name=Spc25 {ECO:0000250|UniProtKB:Q9V3V7}; ORFNames=GH18360;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1] {ECO:0000312|EMBL:EDV93261.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00 {ECO:0000312|EMBL:EDV93261.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       Ndc80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity during meiosis and mitosis. Required for
CC       kinetochore integrity and the organization of stable microtubule
CC       binding sites in the outer plate of the kinetochore. Participates in
CC       SAC signaling that responds specifically to disruptions in spindle
CC       microtubule dynamics. The NDC80 complex synergistically enhances the
CC       affinity of the SKA1 complex for microtubules and may allow the NDC80
CC       complex to track depolymerizing microtubules.
CC       {ECO:0000250|UniProtKB:Q9HBM1, ECO:0000250|UniProtKB:Q9V3V7}.
CC   -!- SUBUNIT: Component of the Ndc80 complex, which is composed of Ndc80,
CC       Nuf2 and Spc25. {ECO:0000250|UniProtKB:Q9V3V7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9V3V7}.
CC       Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q9V3V7}.
CC   -!- SIMILARITY: Belongs to the SPC25 family. {ECO:0000255}.
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DR   EMBL; CH916369; EDV93261.1; -; Genomic_DNA.
DR   RefSeq; XP_001990199.1; XM_001990163.1.
DR   AlphaFoldDB; B4JEY0; -.
DR   SMR; B4JEY0; -.
DR   STRING; 7222.FBpp0152266; -.
DR   EnsemblMetazoa; FBtr0153774; FBpp0152266; FBgn0125828.
DR   GeneID; 6563035; -.
DR   KEGG; dgr:6563035; -.
DR   eggNOG; ENOG502RVT8; Eukaryota.
DR   HOGENOM; CLU_1246541_0_0_1; -.
DR   InParanoid; B4JEY0; -.
DR   OMA; SNELMEC; -.
DR   OrthoDB; 1350883at2759; -.
DR   PhylomeDB; B4JEY0; -.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   GO; GO:0031262; C:Ndc80 complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051311; P:meiotic metaphase plate congression; ISS:UniProtKB.
DR   GO; GO:0000212; P:meiotic spindle organization; ISS:UniProtKB.
DR   GO; GO:0007080; P:mitotic metaphase plate congression; ISS:UniProtKB.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Meiosis; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..209
FT                   /note="Kinetochore protein Spc25"
FT                   /id="PRO_0000392417"
FT   COILED          74..107
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   209 AA;  23900 MW;  4BA71B7B959D861F CRC64;
     MTEQFDTRRR LMAMFRNEMR MEKLENTIAK KSTKFHTNSA ALMTTIDLQQ RKFEKLNALI
     TRRCEDINTR TAFTRAVREK LAEERQKNAE MQAQLEKAND ERIEQMDCVR TLSDASNTFI
     NPSALPARLK GVTVLREEGR WISLDYDGDD LKGLSTFWAQ AHSGSASQKW QQLLSMDKAI
     MPTLNDKGNV NVSVSSIIEI DLTASPSHK