ID   SPC25_DROMO             Reviewed;         208 AA.
AC   B4K8J8;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Kinetochore protein Spc25 {ECO:0000250|UniProtKB:Q9V3V7};
GN   Name=Spc25 {ECO:0000250|UniProtKB:Q9V3V7}; ORFNames=GI23349;
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230;
RN   [1] {ECO:0000312|EMBL:EDW14397.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22 {ECO:0000312|EMBL:EDW14397.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       Ndc80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity during meiosis and mitosis. Required for
CC       kinetochore integrity and the organization of stable microtubule
CC       binding sites in the outer plate of the kinetochore. Participates in
CC       SAC signaling that responds specifically to disruptions in spindle
CC       microtubule dynamics. The NDC80 complex synergistically enhances the
CC       affinity of the SKA1 complex for microtubules and may allow the NDC80
CC       complex to track depolymerizing microtubules.
CC       {ECO:0000250|UniProtKB:Q9HBM1, ECO:0000250|UniProtKB:Q9V3V7}.
CC   -!- SUBUNIT: Component of the Ndc80 complex, which is composed of Ndc80,
CC       Nuf2 and Spc25. {ECO:0000250|UniProtKB:Q9V3V7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9V3V7}.
CC       Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q9V3V7}.
CC   -!- SIMILARITY: Belongs to the SPC25 family. {ECO:0000255}.
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DR   EMBL; CH933806; EDW14397.1; -; Genomic_DNA.
DR   RefSeq; XP_001998936.2; XM_001998900.2.
DR   AlphaFoldDB; B4K8J8; -.
DR   SMR; B4K8J8; -.
DR   STRING; 7230.FBpp0172566; -.
DR   PRIDE; B4K8J8; -.
DR   EnsemblMetazoa; FBtr0174074; FBpp0172566; FBgn0146076.
DR   GeneID; 6572830; -.
DR   eggNOG; ENOG502RVT8; Eukaryota.
DR   HOGENOM; CLU_1246541_0_0_1; -.
DR   InParanoid; B4K8J8; -.
DR   OMA; SNELMEC; -.
DR   OrthoDB; 1350883at2759; -.
DR   PhylomeDB; B4K8J8; -.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   GO; GO:0031262; C:Ndc80 complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051311; P:meiotic metaphase plate congression; ISS:UniProtKB.
DR   GO; GO:0000212; P:meiotic spindle organization; ISS:UniProtKB.
DR   GO; GO:0007080; P:mitotic metaphase plate congression; ISS:UniProtKB.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Meiosis; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..208
FT                   /note="Kinetochore protein Spc25"
FT                   /id="PRO_0000392421"
FT   COILED          31..101
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   208 AA;  23968 MW;  634CB8A49C8CBCFE CRC64;
     MRKRLMAMLQ NDISLQQQEN ALAKQSAKFH SKIAAKHQLI KRQQRKLEKL NQVANERKED
     QENRSAFEQS MRDKLLREQQ NLSEMQTELA TKKQRRDELM GFVRTMSEAT NTYINLKALP
     ARVKGVALRP EQGEWIPFNC DAYDLKGLNA LWSRLNEPSA STDKWQQLFS AEPTAKEKEN
     ANASLSSIIE IDLTSPTAHR SLAKMLEK