SPC25_DROPE
ID SPC25_DROPE Reviewed; 236 AA.
AC B4G5J0;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 43.
DE RecName: Full=Kinetochore protein Spc25 {ECO:0000250|UniProtKB:Q9V3V7};
GN Name=Spc25 {ECO:0000250|UniProtKB:Q9V3V7}; ORFNames=GL24369;
OS Drosophila persimilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234;
RN [1] {ECO:0000312|EMBL:EDW24856.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSH-3 / Tucson 14011-0111.49;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC Ndc80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity during meiosis and mitosis. Required for
CC kinetochore integrity and the organization of stable microtubule
CC binding sites in the outer plate of the kinetochore. Participates in
CC SAC signaling that responds specifically to disruptions in spindle
CC microtubule dynamics. The NDC80 complex synergistically enhances the
CC affinity of the SKA1 complex for microtubules and may allow the NDC80
CC complex to track depolymerizing microtubules.
CC {ECO:0000250|UniProtKB:Q9HBM1, ECO:0000250|UniProtKB:Q9V3V7}.
CC -!- SUBUNIT: Component of the Ndc80 complex, which is composed of Ndc80,
CC Nuf2 and Spc25. {ECO:0000250|UniProtKB:Q9V3V7}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9V3V7}.
CC Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q9V3V7}.
CC -!- SIMILARITY: Belongs to the SPC25 family. {ECO:0000255}.
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DR EMBL; CH479179; EDW24856.1; -; Genomic_DNA.
DR RefSeq; XP_002013870.1; XM_002013834.1.
DR AlphaFoldDB; B4G5J0; -.
DR SMR; B4G5J0; -.
DR STRING; 7234.FBpp0188476; -.
DR EnsemblMetazoa; FBtr0189984; FBpp0188476; FBgn0161959.
DR GeneID; 6587440; -.
DR KEGG; dpe:6587440; -.
DR eggNOG; ENOG502RVT8; Eukaryota.
DR HOGENOM; CLU_1246541_0_0_1; -.
DR OMA; SNELMEC; -.
DR PhylomeDB; B4G5J0; -.
DR Proteomes; UP000008744; Unassembled WGS sequence.
DR GO; GO:0031262; C:Ndc80 complex; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051311; P:meiotic metaphase plate congression; ISS:UniProtKB.
DR GO; GO:0000212; P:meiotic spindle organization; ISS:UniProtKB.
DR GO; GO:0007080; P:mitotic metaphase plate congression; ISS:UniProtKB.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW Kinetochore; Meiosis; Mitosis; Nucleus; Reference proteome.
FT CHAIN 1..236
FT /note="Kinetochore protein Spc25"
FT /id="PRO_0000392423"
FT REGION 194..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 44..106
FT /evidence="ECO:0000255"
FT COMPBIAS 197..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 236 AA; 26615 MW; B6C58878B5F052EF CRC64;
MADLKASEGD LSDYYMRLKK IFSNETRLQS REASISKRSS RVHKNIISAK EAIERQERDF
GKLQKVLLNR NQELERRFTL GEALAQQLEV TRQRNADMEA QLLRHTTEGR QRSNELMECM
HSLKQATGTY INHEALPARL NGVSVVRADD GDIKLIPFSL DGNDADGLHT LWRSLHTRTD
NNASKWRKLI SDQEVAGASP VTPSGSERPK ATSKHSNFMP TSIIEIDLTS PTNDAS
