ID   SPC25_DROVI             Reviewed;         210 AA.
AC   B4M3W0;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Kinetochore protein Spc25 {ECO:0000250|UniProtKB:Q9V3V7};
GN   Name=Spc25 {ECO:0000250|UniProtKB:Q9V3V7}; ORFNames=GJ10343;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1] {ECO:0000312|EMBL:EDW59321.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87 {ECO:0000312|EMBL:EDW59321.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       Ndc80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity during meiosis and mitosis. Required for
CC       kinetochore integrity and the organization of stable microtubule
CC       binding sites in the outer plate of the kinetochore. Participates in
CC       SAC signaling that responds specifically to disruptions in spindle
CC       microtubule dynamics. The NDC80 complex synergistically enhances the
CC       affinity of the SKA1 complex for microtubules and may allow the NDC80
CC       complex to track depolymerizing microtubules.
CC       {ECO:0000250|UniProtKB:Q9HBM1, ECO:0000250|UniProtKB:Q9V3V7}.
CC   -!- SUBUNIT: Component of the Ndc80 complex, which is composed of Ndc80,
CC       Nuf2 and Spc25. {ECO:0000250|UniProtKB:Q9V3V7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9V3V7}.
CC       Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q9V3V7}.
CC   -!- SIMILARITY: Belongs to the SPC25 family. {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH940652; EDW59321.1; -; Genomic_DNA.
DR   RefSeq; XP_002056209.1; XM_002056173.2.
DR   AlphaFoldDB; B4M3W0; -.
DR   SMR; B4M3W0; -.
DR   STRING; 7244.FBpp0224760; -.
DR   EnsemblMetazoa; FBtr0226268; FBpp0224760; FBgn0197629.
DR   GeneID; 6632413; -.
DR   KEGG; dvi:6632413; -.
DR   eggNOG; ENOG502RVT8; Eukaryota.
DR   HOGENOM; CLU_1246541_0_0_1; -.
DR   InParanoid; B4M3W0; -.
DR   OMA; SNELMEC; -.
DR   OrthoDB; 1350883at2759; -.
DR   PhylomeDB; B4M3W0; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0031262; C:Ndc80 complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051311; P:meiotic metaphase plate congression; ISS:UniProtKB.
DR   GO; GO:0000212; P:meiotic spindle organization; ISS:UniProtKB.
DR   GO; GO:0007080; P:mitotic metaphase plate congression; ISS:UniProtKB.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Meiosis; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..210
FT                   /note="Kinetochore protein Spc25"
FT                   /id="PRO_0000392428"
FT   COILED          42..106
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   210 AA;  23882 MW;  1324E2794A0F5209 CRC64;
     MSNQFNTRKR LMAMLANEMR LEQEENAIAK QSAKFHSKFA TTMENIKRQQ HESKKLNTLL
     NQRRDEVEKR NALKNAVRDK LAEEEQHCAE MQAQLGKKKQ ERDKLIACAH ILSEAANTYI
     NRKALPERVK GVAVSPDNGQ WIPFDFNAHD RQGLAALWTQ VNRSSRNINK WRQLSSVGNS
     SMPAPSGKEN ANVSMTSVIE IDLTSPPSQK