ID   SPC25_KLULA             Reviewed;         227 AA.
AC   Q6CUV0;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Probable kinetochore protein SPC25;
GN   Name=SPC25; OrderedLocusNames=KLLA0C02079g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC       SPC24 and SPC25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P40014}.
CC       Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:P40014}.
CC       Note=Associated with kinetochores. {ECO:0000250|UniProtKB:P40014}.
CC   -!- SIMILARITY: Belongs to the SPC25 family. {ECO:0000305}.
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DR   EMBL; CR382123; CAH01140.1; -; Genomic_DNA.
DR   RefSeq; XP_452289.1; XM_452289.1.
DR   AlphaFoldDB; Q6CUV0; -.
DR   SMR; Q6CUV0; -.
DR   STRING; 28985.XP_452289.1; -.
DR   PRIDE; Q6CUV0; -.
DR   EnsemblFungi; CAH01140; CAH01140; KLLA0_C02079g.
DR   GeneID; 2892694; -.
DR   KEGG; kla:KLLA0_C02079g; -.
DR   eggNOG; KOG4657; Eukaryota.
DR   HOGENOM; CLU_085127_1_0_1; -.
DR   InParanoid; Q6CUV0; -.
DR   OMA; TTRAQWR; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:InterPro.
DR   InterPro; IPR045143; Spc25.
DR   InterPro; IPR013255; Spc25_C.
DR   PANTHER; PTHR14281; PTHR14281; 1.
DR   Pfam; PF08234; Spindle_Spc25; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..227
FT                   /note="Probable kinetochore protein SPC25"
FT                   /id="PRO_0000246677"
FT   COILED          40..125
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   227 AA;  26120 MW;  86435CC96FB243F0 CRC64;
     MGIDDFNELK LKMDDFQSKI HQFLIKNNQD LATKSETYWN SESEKIKKIE ALKDKLRQLE
     EHQISLEEEF ESSQREVSEV NAQSKAFLTK RDKLIGEREF LHKELDKLDI LLKEQTKDLE
     REKQSRLLQS SKDTNEVALF ETLLGLHISA NAQDAITFHF TSRTVDVSPQ LSITLDVSQD
     TYKITDSNPK LPQIIKNDLL NNLAATDDLR SFLKAARSHL SALTEAT