ID   SPC25_NEUCR             Reviewed;         259 AA.
AC   Q873B7; A7UWW1; Q7SCC6;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Probable kinetochore protein spc25;
DE   AltName: Full=Kinetochore protein 4;
GN   Name=kpr-4; Synonyms=spc25; ORFNames=B24N11.070, NCU06753, NCU11159;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of kpr-1/ndc80,
CC       kpr-2/nuf2, kpr-3/spc24 and kpr-4/spc25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPC25 family. {ECO:0000305}.
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DR   EMBL; BX284751; CAD70393.1; -; Genomic_DNA.
DR   EMBL; CM002237; EDO65069.1; -; Genomic_DNA.
DR   RefSeq; XP_001728160.1; XM_001728108.2.
DR   AlphaFoldDB; Q873B7; -.
DR   SMR; Q873B7; -.
DR   STRING; 5141.EFNCRP00000006798; -.
DR   EnsemblFungi; EDO65069; EDO65069; NCU11159.
DR   GeneID; 5847309; -.
DR   KEGG; ncr:NCU11159; -.
DR   VEuPathDB; FungiDB:NCU11159; -.
DR   HOGENOM; CLU_065188_0_0_1; -.
DR   OMA; HEDQRMK; -.
DR   Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR   GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:InterPro.
DR   InterPro; IPR045143; Spc25.
DR   InterPro; IPR013255; Spc25_C.
DR   PANTHER; PTHR14281; PTHR14281; 1.
DR   Pfam; PF08234; Spindle_Spc25; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..259
FT                   /note="Probable kinetochore protein spc25"
FT                   /id="PRO_0000246678"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          59..162
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   259 AA;  30198 MW;  7C6EA33A0CED5585 CRC64;
     MSRKSVMSST FEPSLSTSRQ PLGPSLADTL PSINFGFDEL RDRMAKFTAK FDAFIEQGRK
     RVLEERNQFR MNVAELQEDQ RMKKKDIEIL QLKTNTYQQT MAKEAAETRE MQAAIASLTE
     QRDKQAAMRD ALKEQIAATQ REIDARLAAQ RAHAAQLEAQ ARYNVPELDF WVTNLCMRIE
     GAGAEDRLKF VYTHIDERNW EREAWFELSM SGRDYDVRHC RPKLEREKVE KVLDRVNETR
     ELVVLLKGMR ELFVEAMKS