ID   SPC25_YARLI             Reviewed;         232 AA.
AC   Q6CGV4;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Probable kinetochore protein SPC25;
GN   Name=SPC25; OrderedLocusNames=YALI0A15884g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC       SPC24 and SPC25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P40014}.
CC       Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:P40014}.
CC       Note=Associated with kinetochores. {ECO:0000250|UniProtKB:P40014}.
CC   -!- SIMILARITY: Belongs to the SPC25 family. {ECO:0000305}.
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DR   EMBL; CR382127; CAG84039.1; -; Genomic_DNA.
DR   RefSeq; XP_500108.1; XM_500108.1.
DR   AlphaFoldDB; Q6CGV4; -.
DR   SMR; Q6CGV4; -.
DR   STRING; 4952.CAG84039; -.
DR   EnsemblFungi; CAG84039; CAG84039; YALI0_A15884g.
DR   GeneID; 2906159; -.
DR   KEGG; yli:YALI0A15884g; -.
DR   VEuPathDB; FungiDB:YALI0_A15884g; -.
DR   HOGENOM; CLU_1205164_0_0_1; -.
DR   InParanoid; Q6CGV4; -.
DR   OMA; HEDQRMK; -.
DR   Proteomes; UP000001300; Chromosome A.
DR   GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:InterPro.
DR   InterPro; IPR045143; Spc25.
DR   InterPro; IPR013255; Spc25_C.
DR   PANTHER; PTHR14281; PTHR14281; 1.
DR   Pfam; PF08234; Spindle_Spc25; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..232
FT                   /note="Probable kinetochore protein SPC25"
FT                   /id="PRO_0000246679"
FT   COILED          27..126
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   232 AA;  27063 MW;  029CACB9ED0635D6 CRC64;
     MTTLPTLPPL PEDIVTGMEE LKIVMSAALE RQRSQLVQSR QDVNRVLKEL EEESKGVSLE
     IESHMARQHD LRLQISELDK QIEDSKGTIV EYSRRRSELE SKVEAAQRAC DEGRQRLEEQ
     QSLRRRQVQH VMEQSVRNVP ELMYMEDLLG MKIEAVQDDQ LRFVFVKLDP NDYAREFAFV
     LDMADVNYRV EQLEPTLDLS VVDRVVGKLN SSRNFPQFLK EIRQAFKDAI ME