ID   SPC3_STRPU              Reviewed;         208 AA.
AC   P16537;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Protein SPEC3;
GN   Name=SPEC3;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=2828169; DOI=10.1101/gad.1.10.1280;
RA   Eldon E.D., Angerer L.M., Angerer R.C., Klein W.H.;
RT   "Spec3: embryonic expression of a sea urchin gene whose product is involved
RT   in ectodermal ciliogenesis.";
RL   Genes Dev. 1:1280-1292(1987).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=2407617; DOI=10.1101/gad.4.1.111;
RA   Eldon E.D., Montpetit I.C., Nguyen T., Decker G., Valdizan M.C.,
RA   Klein W.H., Brandhorst B.P.;
RT   "Localization of the sea urchin Spec3 protein to cilia and Golgi complexes
RT   of embryonic ectoderm cells.";
RL   Genes Dev. 4:111-122(1990).
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000269|PubMed:2407617}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:2407617}. Cell projection, cilium
CC       {ECO:0000269|PubMed:2407617}. Note=In cilia and Golgi complexes.
CC   -!- SIMILARITY: Belongs to the SPEC3 family. {ECO:0000305}.
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DR   PIR; A43696; A43696.
DR   AlphaFoldDB; P16537; -.
DR   eggNOG; ENOG502S270; Eukaryota.
DR   HOGENOM; CLU_1322394_0_0_1; -.
DR   InParanoid; P16537; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026673; SPEC3/Stum.
DR   PANTHER; PTHR21676; PTHR21676; 1.
DR   Pfam; PF15795; Spec3; 1.
PE   3: Inferred from homology;
KW   Cell projection; Cilium; Glycoprotein; Golgi apparatus; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..208
FT                   /note="Protein SPEC3"
FT                   /id="PRO_0000072108"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..32
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..60
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        71
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   208 AA;  21719 MW;  4BE0638F1DE63C2E CRC64;
     MAQVAPTGAP TDAPPAYPPP PQQAPPPQQP GYGQPQLGYG QPPPQLGYGQ PPPQLGYGYP
     PPPQNNNMMM NNTVVVTAPA PAPANNVVII NQKKDNCCRQ AIPAHHIAAA ILCLIFNIFF
     PGIGTIIAGF AVFCCGNPGA DGGSKVGTMC INFWIGLLQI GTVWFFFLGW IWSIMWGAAF
     IGMSADYHSG GDTTIVATGG GGTTVINN