ID   SPC42_KLULA             Reviewed;         316 AA.
AC   Q6CL89;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Spindle pole body component SPC42;
GN   Name=SPC42; OrderedLocusNames=KLLA0F04862g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Forms a polymeric layer at the periphery of the spindle pole
CC       body (SPB) central plaque which has an essential function during SPB
CC       duplication and may facilitate attachment of the SPB to the nuclear
CC       membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       microtubule organizing center, spindle pole body {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPC42 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382126; CAG98008.1; -; Genomic_DNA.
DR   RefSeq; XP_455300.1; XM_455300.1.
DR   AlphaFoldDB; Q6CL89; -.
DR   SMR; Q6CL89; -.
DR   STRING; 28985.XP_455300.1; -.
DR   EnsemblFungi; CAG98008; CAG98008; KLLA0_F04862g.
DR   GeneID; 2895923; -.
DR   KEGG; kla:KLLA0_F04862g; -.
DR   eggNOG; ENOG502RYX7; Eukaryota.
DR   HOGENOM; CLU_056211_0_0_1; -.
DR   InParanoid; Q6CL89; -.
DR   OMA; HNHATHR; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021611; Spc42.
DR   Pfam; PF11544; Spc42p; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome.
FT   CHAIN           1..316
FT                   /note="Spindle pole body component SPC42"
FT                   /id="PRO_0000409209"
FT   REGION          78..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          224..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          281..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          32..223
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        78..102
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        103..117
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        224..254
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   316 AA;  37183 MW;  304518C11E26DAEE CRC64;
     MIHNGSTPRR FVFGNNDANE RIVPEEYKYN SSMINELIKQ NKDLHKQVTE KQEEIDRLNV
     LIGSFRAKLI KYTELNKKMQ RDQQEQQHNR HQSFESKPRY KAEFTSESSS PVSNERDSEY
     LQIKKNNRHD ENKIDDIYQK LELLTNLVND AIHKQNNGEQ REPSNFNSRI VSDDDIIISE
     SQEFKQLQDQ IDLLKRKLLI KKENELRKLS LNKELADLMD ELSMNSSPSA NQNIDPYSEL
     SSRPKSGQQR RTNEDQQSLH CEHCHLKSHT QSHPSEPRFV NLKESLETPT PTPTQTPRKL
     KREKDTNVAD KQYSLW