SPC98_DICDI
ID SPC98_DICDI Reviewed; 813 AA.
AC Q95ZG4; Q54QB5;
DT 02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Spindle pole body component 98;
DE AltName: Full=DdSpc98;
DE Short=Spc98;
GN Name=spc98; ORFNames=DDB_G0283909;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 2-813.
RC STRAIN=AX2;
RX PubMed=12018385; DOI=10.1078/0171-9335-00241;
RA Daunderer C., Graf R.O.;
RT "Molecular analysis of the cytosolic Dictyostelium gamma-tubulin complex.";
RL Eur. J. Cell Biol. 81:175-184(2002).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=16512674; DOI=10.1021/pr050350q;
RA Reinders Y., Schulz I., Graef R., Sickmann A.;
RT "Identification of novel centrosomal proteins in Dictyostelium discoideum
RT by comparative proteomic approaches.";
RL J. Proteome Res. 5:589-598(2006).
CC -!- FUNCTION: May be involved in microtubule nucleation.
CC -!- SUBUNIT: Gamma-tubulin small complex (Gamma TuSC) consists of gamma-
CC tubulin and SPC98.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome. Cytoplasm.
CC -!- SIMILARITY: Belongs to the TUBGCP family. {ECO:0000305}.
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DR EMBL; AAFI02000058; EAL65442.1; -; Genomic_DNA.
DR EMBL; AJ318507; CAC47948.1; -; mRNA.
DR RefSeq; XP_638829.1; XM_633737.1.
DR AlphaFoldDB; Q95ZG4; -.
DR SMR; Q95ZG4; -.
DR IntAct; Q95ZG4; 2.
DR STRING; 44689.DDB0191482; -.
DR PaxDb; Q95ZG4; -.
DR EnsemblProtists; EAL65442; EAL65442; DDB_G0283909.
DR GeneID; 8624353; -.
DR KEGG; ddi:DDB_G0283909; -.
DR dictyBase; DDB_G0283909; spc98.
DR eggNOG; KOG2000; Eukaryota.
DR HOGENOM; CLU_003736_2_0_1; -.
DR InParanoid; Q95ZG4; -.
DR OMA; MINLWIN; -.
DR PhylomeDB; Q95ZG4; -.
DR PRO; PR:Q95ZG4; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005813; C:centrosome; IDA:dictyBase.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000923; C:equatorial microtubule organizing center; IBA:GO_Central.
DR GO; GO:0000930; C:gamma-tubulin complex; IBA:GO_Central.
DR GO; GO:0008275; C:gamma-tubulin small complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR GO; GO:0043015; F:gamma-tubulin binding; IDA:dictyBase.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IBA:GO_Central.
DR GO; GO:0007020; P:microtubule nucleation; IBA:GO_Central.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0051225; P:spindle assembly; IBA:GO_Central.
DR Gene3D; 1.20.120.1900; -; 1.
DR InterPro; IPR007259; GCP.
DR InterPro; IPR040457; GCP_C.
DR InterPro; IPR042241; GCP_C_sf.
DR InterPro; IPR041470; GCP_N.
DR PANTHER; PTHR19302; PTHR19302; 1.
DR Pfam; PF04130; GCP_C_terminal; 1.
DR Pfam; PF17681; GCP_N_terminal; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Microtubule; Reference proteome.
FT CHAIN 1..813
FT /note="Spindle pole body component 98"
FT /id="PRO_0000078122"
FT REGION 69..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..439
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 813 AA; 94434 MW; 59FC6CE25E18EAAD CRC64;
MNSTFVQIPK LNINKQVKKK TDSITANTLL PKLMNDTSIQ QPNQQQQQQQ PQQPQQVTNG
ITILQNYQPQ QPQPATTTTQ QLNSANNTPT LVSTKKSVIG INEIPEHLLI RDIIYVFQGI
DGTYIKYNKQ SDSFKIDENT SNTLVNGEPA YISKPKRDLV YRLCEFGWLF KKVRLFITNN
DFKKTGLTNQ SFCSAINDEL IELYRIIAIL ETQVYKKFDM VNYGGGGGGS GGSGSGSGLE
SPSSVSSGGT TTSTEIPFID GDSLTLIRLF VWIQSPLKRL KVLGTCVDSI TVDMKGGEIL
SKIDTLSKHG DQDIRILIHN IMFKICQPLF SMIRLWMFKG EINDPYQEFF IRQYESVQLE
KTWKEKFAIV ARLLPSFISL PLSKRILIIG KSINYMKQFC NNFKEDKNDR YYYYNQEDDD
DDDEDHDDND DDDENENQGE DDEIIERKLL IKESKIIKEK TKELNYINKE VLQEIIELVS
RQSSERLLKI VLNRFKFMNH VKALKKYLLL GQGDFIQYLM DLIGEDLLKP TSQIQRHKLV
GWMDTAIRNS NAQFEEQDIV NRLDIALLPE RPGNIGWDIF SLDYHVDTPL NTILSPNDIL
RYKKIFHFMW GIKRVEYSLA SIWRKIRSST SLSILSPIGG DIHKSHLIMN EMVHFISNFQ
YYLMFEVLEC SWKNLEKFID QEATDLDQLI EAHHQYLQDI CNKMFLSNSD SCYECFKKLL
SIIIKFTLLQ TKLINLSIAI QNEKNFNETH QAQVNKEFNS FRNHLNNLYQ EYTTSFYKFQ
SEILKVKVNQ DLNPISLQYM LDFNEYYEEK KDN
