SPCS1_CAEEL
ID SPCS1_CAEEL Reviewed; 105 AA.
AC O44953;
DT 31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Signal peptidase complex subunit 1;
DE AltName: Full=Microsomal signal peptidase 12 kDa subunit;
DE Short=SPase 12 kDa subunit;
GN Name=spcs-1 {ECO:0000312|WormBase:C34B2.10};
GN ORFNames=C34B2.10 {ECO:0000312|WormBase:C34B2.10};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Component of the signal peptidase complex (SPC) which
CC catalyzes the cleavage of N-terminal signal sequences from nascent
CC proteins as they are translocated into the lumen of the endoplasmic
CC reticulum (By similarity). Dispensable for SPC enzymatic activity (By
CC similarity). {ECO:0000250|UniProtKB:P46965,
CC ECO:0000250|UniProtKB:Q9Y6A9}.
CC -!- SUBUNIT: Component of the signal peptidase complex (SPC) composed of a
CC catalytic subunit sec-11 and three accessory subunits spcs-1, spcs-2
CC and spcs-3. The complex induces a local thinning of the ER membrane
CC which is used to measure the length of the signal peptide (SP) h-region
CC of protein substrates. This ensures the selectivity of the complex
CC towards h-regions shorter than 18-20 amino acids.
CC {ECO:0000250|UniProtKB:Q9Y6A9}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:P83362}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P83362}.
CC -!- SIMILARITY: Belongs to the SPCS1 family. {ECO:0000305}.
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DR EMBL; BX284601; CCD62128.1; -; Genomic_DNA.
DR PIR; T32884; T32884.
DR RefSeq; NP_492797.1; NM_060396.4.
DR AlphaFoldDB; O44953; -.
DR SMR; O44953; -.
DR STRING; 6239.C34B2.10; -.
DR EPD; O44953; -.
DR PaxDb; O44953; -.
DR PeptideAtlas; O44953; -.
DR EnsemblMetazoa; C34B2.10.1; C34B2.10.1; WBGene00016395.
DR GeneID; 172967; -.
DR KEGG; cel:CELE_C34B2.10; -.
DR UCSC; C34B2.10.1; c. elegans.
DR CTD; 172967; -.
DR WormBase; C34B2.10; CE16898; WBGene00016395; spcs-1.
DR eggNOG; KOG4112; Eukaryota.
DR GeneTree; ENSGT00390000018321; -.
DR HOGENOM; CLU_134505_1_1_1; -.
DR InParanoid; O44953; -.
DR OMA; WPIYRRS; -.
DR OrthoDB; 1589808at2759; -.
DR PhylomeDB; O44953; -.
DR PRO; PR:O44953; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00016395; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:WormBase.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0005787; C:signal peptidase complex; IBA:GO_Central.
DR GO; GO:0045047; P:protein targeting to ER; IBA:GO_Central.
DR GO; GO:0006465; P:signal peptide processing; IBA:GO_Central.
DR InterPro; IPR037713; Spc1.
DR InterPro; IPR009542; Spc1/SPCS1.
DR PANTHER; PTHR13202; PTHR13202; 1.
DR PANTHER; PTHR13202:SF0; PTHR13202:SF0; 1.
DR Pfam; PF06645; SPC12; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..105
FT /note="Signal peptidase complex subunit 1"
FT /id="PRO_0000215158"
FT TOPO_DOM 1..32
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P83362"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..56
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:P83362"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..105
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P83362"
SQ SEQUENCE 105 AA; 11777 MW; 1C041B5D94A5C471 CRC64;
MDGMIAMLPA PLQKLSSHID FQGQKVAERT YQVILTIAGI IGFLVGFWTQ QLSYAMFTVL
GASAFTALII LPPWPFLFRK NPIVWHTPAE PQESGDKKKE TKKTK